One Way Tech Hubs | Software Engineers | Remote (US) | Full-Time

We’re hiring experienced software engineers for fully remote positions open to candidates based in the US.

We’re looking for engineers with 3+ years of professional experience in areas including:

• Full-Stack Engineering • Backend / Frontend Engineering • Python • Cloud Infrastructure / DevOps • AI / Machine Learning • Data Engineering

Candidates should have strong hands-on engineering experience and be comfortable working independently in a remote environment.

To apply, send your resume to hassanonewaytech@gmail.com.

Prior Labs | Berlin, Freiburg, NYC | ONSITE | Full-time | ML Infra, Research Scientist/Engineer, Backend, Full Stack

We build foundation models for tabular data. Deep learning transformed text and images but mostly skipped tables, which are still the data behind most clinical trials, financial models and scientific experiments. The reason is structural: no natural sequence, no spatial structure, no shared vocabulary across datasets, so the architectures and scaling laws behind LLMs don't transfer.

Our approach: pre-train a transformer on millions of synthetic datasets sampled from causal-structure priors. The whole dataset goes in as context, predictions come out in one forward pass. No per-dataset training, no hyperparameter tuning, seconds instead of hours. TabPFN v2 was published in Nature and set a new state of the art; TabPFN-3 scales to 10M rows. 4M+ downloads, 8k+ GitHub stars, in production from liquid biopsy to rail maintenance. Code: https://github.com/PriorLabs/TabPFN

Since July we're an independent lab inside SAP, with more than EUR 1B committed over four years. Models stay open, research stays public, same team and offices.

Roles (most can sit in any of the three offices):

- Senior ML Infrastructure Engineer: own multi-cluster GPU infra (Slurm on GCP today, multi-provider next), training performance and the tooling layer. We spend tens of millions per year on compute; you own that budget.

- Research Scientist, Foundation Model: drive the model agenda - novel architectures, scaling from 10K to 1M+ samples, multimodal and causal directions. PhD plus top-venue publications, or equivalent.

- Research Engineer, Foundation Model: same agenda from the engineering side. You design experiments, write the training and eval infra, and co-author the papers.

- ML Engineer, Cloud Platform: design and scale the backend that serves and finetunes the models. Python/FastAPI, Terraform, K8s.

- Full Stack Engineer, ML Platform: build the product end to end. TypeScript + Python, React/FastAPI/Postgres.

Also hiring: Applied Scientist, Forward Deployed ML Engineer, Research Scientist (Foundational Data Science), PhD research interns, plus GTM and ops roles.

~40 people with backgrounds from Google, DeepMind, Jane Street, Goldman, G-Research, CERN. Led by Frank Hutter, advised by Bernhard Schölkopf and Yann LeCun. Comp competitive with top AI labs.

All roles and applications: https://jobs.ashbyhq.com/prior-labs

Questions welcome in the replies here.

Strobe Power | Site Reliability Engineer | ONSITE (SF) | https://strobepower.com

AI data centers are creating a massive new wave of electricity demand and putting even more strain on an aging grid. Strobe is building the power company that will meet that demand.

Our software turns batteries and generators at commercial and industrial buildings into distributed power plants that can buy, sell, and dispatch electricity in real time. We build the control stack for operating these assets and the trading platform that connects them to wholesale energy markets.

We’re a small, high-ownership team working on critical infrastructure. You’ll learn how the energy system actually works: what happens inside the electrical room of a large commercial building, how data centers are powered, how utilities and grid operators communicate, and how a battery gets commissioned and brought online.

This is early, technical, and very real-world. The software you build will control physical equipment, keep power plants online, and move money in regulated markets. We’re the only company actively trading distributed power in FERC-regulated wholesale markets, with multiple behind-the-meter power plants operating in NYC and expansion underway in California and along the East Coast.

I’m looking for an experienced SRE to own our infrastructure and reliability. We remotely operate millions of dollars of equipment, and it has to work. You’ll own our AWS environment, the control-room infrastructure that communicates directly with utilities and market operators, and the systems we use to deploy, observe, and operate a growing fleet. You’ll also work closely with the rest of the engineering team to establish good patterns as we ship new services and features.

You’re probably a good fit if you have deep AWS experience, have used Terraform seriously in production, write a lot of Python, and are comfortable working around Rust services. Energy experience is useful but not required (SCADA, DNP3, MQTT).

Stack: Python, TypeScript, Rust, Terraform, AWS, GraphQL/AppSync, MQTT, Grafana. We work in a monorepo designed for agent-assisted engineering workflows and are investing heavily in making engineers dramatically more effective with coding agents.

Apply: keeley@strobepower.com or https://strobepower.com/careers. Please mention Hacker News.

Lokker.com | Data Scientist, Classification and Scoring | REMOTE: North America / Europe, UTC-8 to UTC+2 | Full-time

Lokker is a privacy platform. We continuously analyze websites, applications, third-party technologies and data flows to identify privacy, security and consent risks in production. We have built a large proprietary dataset from years of observing real-world digital behavior, and we are hiring a data scientist to help us expand and improve the classification, scoring and risk intelligence built on it.

You will develop and improve models that classify digital activity, identify meaningful privacy and security behaviors, and assess the confidence and significance of findings.

Looking for 2 to 4 years of production experience in data science and machine learning. Strong Python and SQL, pandas or Polars, scikit-learn and modern classification techniques, familiarity with model evaluation and explainability. Practical experience in training and evaluating supervised classification models on real PRODUCTION data, practical LLM experience beyond simple demonstrations, and curiosity about how websites and internet technologies actually behave. You do not need a privacy or adtech background. We will teach the domain.

You will work closely with engineering, product and privacy experts, and what you build goes directly into the product.

IMPORTANT: the timezone range above is a hard requirement, not a preference. We cannot make an exception.

ON APPLICATIONS: we assume you used AI to help write it. So do we. What we cannot do is verify a claim that exists only in the document you sent us, so make sure the skills you claim are visible somewhere public: LinkedIn with real dates and role detail, GitHub, papers, Kaggle, a writeup, a talk. If your best work is under NDA, say so and describe it in your own words.

A human reads every application. No keyword filter, no automated rejection.

Apply: https://lokker.com/careers/openings/data-scientist-classific...

Spanish National Cancer Research Centre (CNIO) | Madrid, Spain | HYBRID | Senior Scientific Computing Engineer | Full-time

CNIO is one of Europe's leading cancer research centres. We're looking for a senior scientific computing engineer to join the IT, Scientific Computing and AI area and take ownership of the infrastructure behind our research, from genomics pipelines to AI models. You'll be the senior scientific computing person in the area, reporting directly to me (the area head), and you'll help define where scientific computing at CNIO goes over the next few years.

What you'll do:

- Shape the roadmap for scientific computing at the centre and drive it forward

- Own and evolve our HPC cluster (Slurm): scheduling, monitoring, capacity planning, user support

- Build out our GPU / AI infrastructure as the centre's ML workloads grow

- Work with researchers to turn their analyses into robust, reproducible pipelines and tools

- Optional: co-author research papers

What we're looking for:

- Several years running Linux HPC environments in production (Slurm or similar)

- Comfortable with automation (Ansible, Python), containers (Apptainer/Docker) and workflow managers (Nextflow, Snakemake or similar)

- Someone who wants to set direction, not just keep the lights on

- Bonus: Ceph, Kubernetes, GPU stacks, a bioinformatics background

- Spanish not required

If interested: tdidomenico-at-cnio-dot-es.

Odoo | Software Developer | Hybrid (Belgium, 3 days/week) | Full-time | Visa + €10k Signing Bonus | https://www.odoo.com/r/4zN

Odoo builds open-source business apps used by millions. We're hiring software developers to work on our Python/PostgreSQL backend, fast JS framework, mobile apps, website builder, and more.

Why join us:

- €10k signing bonus - Visa sponsorship + relocation support (contains flight ticket + airport taxi + 1 month free housing) - No clients, no deadlines — just clean, open-source code - Pick your team after 3 weeks of onboarding - Great team, countryside office (with chef!), flexible hours

You:

- Master a programming language - Proficiency in object-oriented programming - Strong in SQL and relational database, data structures, and DB design - Passionate, autonomous, and eager to build real stuff

Apply → https://www.odoo.com/r/4zN

Axmed | AI Engineer | REMOTE (preferred Spain, UK, Poland, Romania) | Full-time | apply: axmed.teamtailor.com/jobs/8175859-ai-engineer

Axmed runs a live B2B marketplace connecting healthcare providers in low- and middle-income countries with pharmaceutical suppliers, working to make sure geography and income never stand between someone and the medicine they need. Backed by the Gates Foundation and Founderful. We're past proving it works and into scaling it — this role is what takes us there.

You'll design and ship autonomous agents that run real steps of the marketplace (sourcing, quoting, order matching, supplier follow-up) on real transactions and real money, with a human in the loop where risk demands it. Full lifecycle ownership: you decide the approach, build it, ship it, watch it, fix it.

Stack: Python, your choice of orchestration framework (LangChain/LangGraph/LlamaIndex/CrewAI), LLM APIs, cloud infra, CI/CD.

We are a fully remote, global team of 55. No visa sponsorship/relocation.

Apply: axmed.teamtailor.com/jobs/8175859-ai-engineer

Multiply | Python + SQL Software Engineer | On-site | Mauritius

We build repricing software that keeps online sellers on top of their competition on 130+ marketplaces.

You’ll work on pricing algorithms, high-volume data ingestion, marketplace integrations, scalability, and enabling our product to be used by AI agents.

We’re looking for someone with extensive experience building data-intensive web applications backed by relational databases, and who is comfortable designing, deploying, operating, debugging, scaling and evolving production systems.

Stack: Python, Postgres, FastAPI, SQLAlchemy.

Our office is beautifully located in Mauritius. We sponsor visas and handle all relocation/immigration.

Apply: jobs@multiply.cloud

Senior Python Backend Engineer | REMOTE (EMEA/APAC)

We're looking for Python backend engineers to work on a trustless supercluster of performance-proofed GPU-enabled sandboxed docker container runners controlled by truly decentralized algorithms (not just PAXOS or RAFT).

Wow, that was a mouthful...

If you found it interesting, join Reef Technologies and tackle complex technical challenges like this on your own terms:

- Contribute from wherever you like; we are fully remote

- Set your own time commitment, as long as it's at least 30h per week

- See how we work in our handbook: github.com/reef-technologies/handbook

- Influence the way we operate through our Sociocracy 3.0 decision-making process

Salary on a B2B contract:

- 45-70 USD or 180-280 PLN per hour

- Flexible work schedule (as measured with a time tracker)

- We automatically adjust rates based on inflation twice a year

We're looking for someone with 5+ years of programming experience, including at least a year with Python (including open-source and significant personal projects).

So, what do you think? You don't even need a CV; just go to https://careers.reef.pl/?utm_source=hackernews and shoot a few quick commands to apply.

Edit: If you applied and haven't heard back, please check the spam folder of the email associated with the GitHub account you used to apply — our replies sometimes end up there.

Stealth (B2B AI for MedTech) | Founding Engineer (AI / RAG, backend-leaning) | Remote (Berlin-based) | Part- or Full-time

We're an early, stealth B2B startup — a Berlin GmbH — bringing reliable, AI-native expertise to the medical-device world, helping the experts who get life-saving innovation to market. Small team, real MVP in progress.

You'd be our first engineering hire: hands-on building the product alongside our senior eng lead, owning big parts of the backend — Python, RAG, and agentic workflows — and growing with the company.

For someone who ships, is genuinely drawn to MedTech and to making expert knowledge accessible, and wants an entrepreneurial role with meaningful equity and broad ownership. Part- or full-time to start; happy to share the full picture over a call.

Email me at engineering@comentic.com — and tell me one thing you've built.

SerpApi | https://serpapi.com | Junior to Senior Fullstack Engineer multiple positions | Customer Success Engineer | Hiring Coordinator | Python/Ruby/PHP/Js/Rust/Cotlin/C#/Crystal/Nim/Elixir Developer Advocate positions | Based in Austin, TX but remote-first structure | Full-time | ONSITE or FULLY REMOTE | $150K - 180K a year 1099 for US or local avg + 20% for outside the US

SerpApi is the leading API to scrape and parse search engine results. We provide 100+ APIs to Google, Google Maps, Google Images, Bing, Baidu, and more.

Our current stack is Ruby, Rails, MongoDB, and React.JS. We are looking for more Junior and Senior FullStack Engineers.

We have an awesome work environment: We are a remote first company (before Covid!). We do continuous integration, continuous deployments, code reviews, code pairings, profit sharing, and most of communication is async via GitHub. We value super strongly transparency, do open books, have a public roadmap, and contribute to the EFF.

Apply at: https://serpapi.com/careers

National Association of Realtors | Chicago or Washington DC - ONSITE | Data Analyst | Full Time

We want Python + Pandas, SQL, statistics, data visualization and some AI; the usual data science stack. Job is in-depth data analysis across multiple data sets - the challenges change weekly. We're using Cursor for data science and AI is permeating all our analysis work - we're transforming from traditional data science to being AI-forward.

Job is here: https://realtors.applicantstack.com/x/detail/a2yfvt49zurx

Greenzie | Robotics Software Engineer (Early Career + Experienced) | Atlanta, GA | ONSITE/HYBRID | Full-time | https://greenzie.applytojob.com/apply

Greenzie builds the autonomy software that runs on commercial mowers. We don't sell the iron — Wright, Mean Green, Bobcat, and Greenworks Commercial do, with our stack on them. Mission is to free humans from repetitive outdoor labor. The software is on hundreds of machines in the field today.

We're hiring roboticists who want production robots doing real outdoor work, not lab demos. C++, Python, ROS/ROS2. You will own (or learn) a subsystem, debug messy field data, and ship to machines that mow for a living.

- Robotics Software Engineer | Early Career (0–3 yrs): https://greenzie.applytojob.com/apply/zaDr7OyOmj/Robotics-So... - Robotics Software Engineer | Experienced (3–6 yrs): https://greenzie.applytojob.com/apply/UdRcDlWSzs/Robotics-So...

Also open in Atlanta: Technical Service Coordinator.

Apply on those pages and mention HN. Questions: cbq@greenzie.com

One Way Tech Hubs | Software Engineers | Remote (US) | Full-Time

We’re hiring experienced software engineers for fully remote positions open to candidates based in the US.

We’re looking for engineers with 3+ years of professional experience in areas including:

• Full-Stack Engineering • Backend / Frontend Engineering • Python • Cloud Infrastructure / DevOps • AI / Machine Learning • Data Engineering

Candidates should have strong hands-on engineering experience and be comfortable working independently in a remote environment.

To apply, send your resume to hassanonewaytech@gmail.com.

Seeq | https://seeq.com | Staff/Principal Software Engineer (Full-Stack, AI, Backend, Platform) | REMOTE (Some crossover w/ PST required) | Full-time | $170k-$205k + annual cash bonus + equity. Salary range for US-based; local adjustments for other countries. Seeq creates cutting-edge data analytics software for industrial process data, serving sectors like pharmaceuticals, energy, and manufacturing. Our core product is a robust calculation engine capable of executing advanced math and machine learning algorithms on streaming time-series data. By leveraging generative AI, we enhance usability and accelerate outcomes for our users. We've built up a great remote culture (e.g. annual meetups, home office allowance, generous PTO, a remote office app we created to collaborate) and a dev team that enjoys tackling hard problems that make a difference for our customers (dev blog for more: https://geeq.seeq.com/).

Be sure to mention that you came from Hacker News in your application!

Staff/Principal Backend Software Engineer (JVM, Postgres): https://apply.workable.com/seeq/j/CDBF1AE73C

Staff Full-Stack (React, Python, AI Technologies): https://apply.workable.com/seeq/j/1378093793

Staff/Principal Full-Stack (React, JVM, Postgres): https://apply.workable.com/seeq/j/610FB07CEB

BCC | Platform Systems Engineers | Bethesda MD | Competitive compensation! | https://www.ncbi.nlm.nih.gov

Black Canyon Consulting (BCC) is hiring Platform Systems Engineers of all levels to join our team at the National Center for Biotechnology Information (NCBI). Our team is dedicated to building cutting-edge tools and systems. Our mission is to empower developers across NCBI to build, deploy, and manage software, data, and web services that make a real difference in the lives of millions of Americans.

Your contributions will play a crucial role in modernizing government technology infrastructure, fostering innovation, and ultimately making a tangible impact on communities across the country and globally. This is your chance to be part of a mission-driven team that’s shaping the future of digital government.

Tech: Linux, k8s, Service Mesh, Kafka, GitLab, ArgoCD, Elastic APM, Python, C++

DevEx Eng: https://job-boards.greenhouse.io/blackcanyonconsulting/jobs/... Sr DevEx Eng: https://job-boards.greenhouse.io/blackcanyonconsulting/jobs/...

Plaform Eng Manager: https://job-boards.greenhouse.io/blackcanyonconsulting/jobs/...

DrSwarm | CTO Cofounder | Bay Area | Full-time

Building AI agents that automate the work of outpatient healthcare practices.

I'm the former co-founder/CEO of DrChrono (YC W11).

Looking for an exceptional hands-on technical cofounder who wants to build a ton of product — not manage an engineering org. You'll code every day, own the architecture, work directly with customers, and help define what we build.

Python/Django, Next.js, Postgres, AWS, LLM/voice/agent infrastructure.

Bay Area strongly preferred. Cofounder-level equity + salary.

Email: jobs@drswarm.com include CTO in email subject

Product Genius | Backend Engineer | REMOTE (US) | Full-time | $165k–$190k + equity

We build real-time learning AI: the APIs and data pipelines connecting live user and merchant behavior to systems that learn from it. Patented tech, backed by $35M in DARPA-funded R&D. AI-native team, you'll use agentic coding tools daily, including running multiple parallel sessions, on a fast-moving codebase. We share context, not tickets.

Looking for 5+ years building production backend systems, hands-on agentic AI coding experience, and experience with APIs/data pipelines feeding analytics or ML systems. Python, SQL, TypeScript, React.

Apply: https://jobs.ashbyhq.com/productgenius/b9f0cb32-612d-45ff-bc...

Biobase | Senior Technical Product Engineer, Technical Product Engineer (Early Career) | REMOTE (US, Canada) | Full-time | $150–230k / $90–170k + equity

Biobase has grand ambitions. We broker biospecimens, whole slide images, and the clinical metadata attached to them, on a supply-chain backbone that we're steadily automating. We’re building healthcare-data-focused agents on top of the datasets that we’re assembling, too.

We'd rather build the thing that removes the work than throw people at it. Two roles, one team, both reporting to the CPO:

Senior Technical Product Engineer ($150–230k + meaningful equity). The product team's technical interface. Architecture decisions and code review on the platform (Python/FastAPI, TypeScript/React, Postgres, Azure); the data pipeline and informatics that take specimen, slide, and clinical data in from suppliers and labs; and product ownership of the internal platform that builds our agents (permissions, evals, cost control, guardrails for sensitive data). You've been the reviewer of record somewhere, you've operated what you shipped, and you think in business problems before tickets.

Technical Product Engineer, early career ($90–170k + equity). Same territory at an earlier stage: the platform, the data pipeline and informatics, and the agents we run against our own operations — with a senior product engineer and our lead engineer reviewing your work and pairing when it helps. Open on background – self-taught, bootcamp, degree, research lab, a career you're leaving – selective on the bar. You've built something and someone else used it.

We build with Claude Code every day and expect you to become both fluent with it and skeptical of it. No ticket queue, no spec handed to you. Comp is salary + equity combos you choose between.

Full postings: https://biobase.ai/careers

To apply: email jobs@biobase.ai with something you built that eliminated manual work and what happened after it shipped. Links over resumes, no cover letter.

Paramark | Software Engineer (L4) | San Francisco HYBRID (3 days/wk) or REMOTE (US) | Full-time | $199K–$249K + equity

Paramark helps Marketing teams optimize spend across all of their channels and programs. There are proven scientific ways to do this, but they are poorly understood and practiced by only a tiny fraction of teams. Our product ingests data from all of our customers' marketing channels and uses it to train open-source ML models for both measurement and experimentation. This makes it possible for any marketer to use these methods.

In this domain, it's hard to figure out what to build, and it's even harder to be both accurate and simple. You'll be joining a small team -- we have four product engineers. That means owning systems end to end and having real influence over what gets built. Your typical project will start with a high level goal, and you will figure out the rest.

Founded 2023, 15 people, $8M from Greylock and others, cash-flow positive. Reasonable working hours: when the Mercury News covered the return of 996 culture, we were the counterexample. "We don't think early stage startup life requires 18-hour days, or even 12-hour days." https://www.mercurynews.com/2025/08/25/silicon-valley-startu.... 4 weeks PTO plus federal holidays, medical/dental/vision (100% of employee premiums, 50% for family).

Looking for 8+ years, full-stack. Some exposure to statistics, experimentation, or A/B testing helps.

Stack: TypeScript, React, Python, Postgres. Google Cloud, Kubernetes, FastAPI, taskiq.

Process: intro call; technical phone screen; one-day onsite in SF (travel covered for remote candidates)

In-person: https://paramark.com/careers/software-engineer-l4

Remote: https://paramark.com/careers/software-engineer-l4-remote

I'm the CTO and I read every application myself. Happy to answer questions in this thread.