Ploid AI | Barcelona, Spain | REMOTE (preferably hybrid) | Core Team | Full-time

We're building an AI-first bioinformatics platform to empower life science researchers with agentic AI and LLMs. Backed by pre-seed funding, a government grant, and customers from biotech, agrotech, and pharma companies, we're looking for a full-stack engineer to join as a core member.

What we're looking for:

• Strong full-stack experience across Go, TypeScript, and Python (Rust is a plus)

• Hands-on AWS infrastructure work (you've built and maintained production cloud environments)

• Experience with multi-tenant architectures: isolation strategies, auth, data partitioning

• Comfort with AI/ML devops: deploying and orchestrating model-serving pipelines, managing GPU workloads, CI/CD for ML systems

• Willingness to own problems end-to-end, from system design to shipping

Nice-to-haves (not all required): LLM integration, RAG systems, HPC infra, cloud/on-prem hybrid systems

About us: We're a team of engineers and scientists with strong academic and industry backgrounds (ex-BCG, PhD in Plant Biotech and Bioinformatics, Mathematics, M.Sc. AI, PhD in Electrical Engineering). We're committed to building something impactful, technical, and genuinely useful for life science.

Apply: hello@ploid.ai

More about us: https://ploid.ai

We also consider internship requests from strong student candidates for research work.

Thanks to everyone who's reached out through previous HN posts, this community has helped us find amazing people.

BioLM | Lead Platform Engineer | San Francisco (or Remote) | Full-time | biolm.ai

We're building an AI platform for molecular discovery: think language models for protein and DNA design. Small founding team, moving fast, real ownership.

Looking for a lead platform engineer to own full-stack development across our Console, Builder, and Solutions apps. You'll ship agentic workflows for molecular design, build integrations with sequence/assay ordering providers, and help shape the technical direction of the platform.

Stack: Python, React, Node.js, AWS, Docker, REST/WebSockets. Bonus if you have experience with agentic systems or MCP. Interest in biology/bioinformatics a plus but not required. If you've shipped production systems end-to-end, have strong product instincts, and want to work on something at the intersection of AI and life sciences - we'd love to hear from you.

https://app.dover.com/apply/BioLM/12435b30-67f1-43c2-8c59-6d...

Onos Health | Staff Eng (AI), Lead Eng (Backend), Lead Eng (Data) | San Francisco (Hybrid) | $200-250k + Equity | [https://onoshealth.com](https://onoshealth.com/)

30 cents of every behavioral health dollar in the U.S. is wasted — on ineffective care, administrative overhead, and outright fraud. Onos fixes this by ensuring every healthcare dollar goes toward high quality care.

Our AI platform helps health plans identify where care is going wrong, get members on the right clinical pathway, catch fraud and abuse, and automate reviews that clinical teams currently do by hand. We're well funded by top healthcare investors and live with some of the nation's largest health plans.

Stack: Python/Django, Next.js/TypeScript, PostgreSQL, AWS (Bedrock, ECS, Glue, S3). We ship with Claude Code and CodeRabbitAI.

Hiring:

- Staff Software Engineer (AI) — LLM pipelines for clinical note extraction, level-of-care classification, eval frameworks - Lead Engineer (Backend) — clinical workflow engine, AI/ML pipeline integration, multi-tenant architecture - Lead Engineer (Data/Integrations) — payer data pipelines, EDI X12/FHIR/HL7, claims feed infrastructure

All roles: https://onoshealth.com/career Email: [joinus@onoshealth.com](mailto:joinus@onoshealth.com) (mention HN)

Mighty Acorn Digital | Remote (Continental US) | Full Time | https://www.mightyacorn.com/

At Mighty Acorn, we make it easier for governments to deliver world-class digital services. From renewing a fishing license to applying for unemployment benefits, we build digital services that enhance public trust and satisfaction.

Our vision is a world where “good enough for government work” returns to its pedestal: fast, reliable, and frustration-free. We achieve this by empowering people, increasing transparency, breaking down silos, and moving together toward a shared goal.

Specializing in modern software development, DevSecOps, and scalable infrastructure, we focus on leveraging automation to manage complexity, accelerate transformation, shorten feedback loops, and reduce risk to build a world where government programs run reliably, smoothly, and efficiently.

We are hiring for the following roles:

- Software Engineer V - Infra/SRE (AWS/Terraform/Typescript) - Software Engineer IV - Full Stack (Typescript/Java)

https://www.mightyacorn.com/careers?utm_source=hackernews

Blackshark AI | Software Engineers & Platform Engineers | Full-time | Austria or Remote EU Hours | VISA sponsorship available

We build geospatial AI infrastructure. Our platform lets analysts train custom object and change detection models on satellite/aerial/drone imagery in minutes, then reconstructs 3D terrain from those detections. We just shipped a planetary-scale simulation platform with Lockheed Martin powered by Unreal Engine.

If you want to work on distributed systems that run in a data center one day and an edge laptop the next, we have interesting problems. Our training and inference infrastructure is processing trillions of pixels and we deliver real world impact for our customers across defense, intelligence, and local governments.

Tech Stack: Python, Fast API, PyTorch, Postgres, Redis, Vue.js

Infrastructure Stack: Kubernetes & Docker, Linux, AWS & Azure, Azure DevOps, Terraform, ELK, Prometheus & Grafana, ArgoCD & Helm

Roles:

Software Engineer - Frontend UI https://jobs.eu.lever.co/blackshark/5c596b85-5134-4601-be25-...

Software Engineer - Data Plane Team: https://jobs.eu.lever.co/blackshark/6110fedd-5cd8-40e5-ac11-...

Platform Engineer - Deployment Team: https://jobs.eu.lever.co/blackshark/56a85834-d986-4105-9cc8-...

or reach out to HM with questions at: 'eivanov@' + username[:-2] + '.' + username[-2:].lower()

ML6 | Machine Learning Engineer, Data Engineer | Python, TensorFlow, PyTorch, GCP, AWS, Azure | Full-time | Amsterdam, Berlin, Munich, Eindhoven, Ghent (EU) On-site/hybrid

We are a Machine Learning consulting company that builds end-to-end Machine Learning solutions. By applying the latest AI research, we keep our clients at the forefront of innovation. If you are interested check out: https://www.ml6.eu/knowledge-hub/blog and https://www.ml6.eu/customers/cases

Work on innovative projects for the biggest clients across Europe such as Randstad, ASML, FUNKE, and many more! Whether it’s about leveraging LLMs to improve customer support, building data lakes on cloud platforms to improve storage or implementing models using sensor data for quality control. You can find it all at ML6. You will mostly work with Python and a range of ML frameworks such as TensorFlow, PyTorch, or HuggingFace Transformers to solve hard Machine Learning tasks and help bring these application into production by building data pipelines and cloud infrastructure on all of the major cloud providers (GCP, AWS, Azure).

Open roles include:

• Senior/medior AI Engineer

• Senior AI Project Manager

• Chief Product Owner

and many more!

Apply now at the https://jobs.ml6.eu/

Evervault | Engineers, Designers, PM | London or Dublin | Fulltime | https://evervault.com

Plaintext is hazmat. Come design the products that kill it.

We are a developer security and API company on a mission to encrypt the web. We sit at the intersection of: Security - we've invested a tonne of time in cryptographic systems and provable secure compute. Blog post - https://evervault.com/blog/optimizing-our-encryption-engine Developer infrastructure - think Cloudflare & AWS Payments - think Stripe, Adyen etc.

We're backed by the some of the biggest VCs and have just closed our Series B, bringing out total funding to over $50m.

All roles here - https://jobs.ashbyhq.com/evervault - please mention Hackernews in submission!

CVector | Software Engineers, Senior Research Engineer | New York City (FiDi) | ONSITE | Full-time | VISA SPONSORSHIP

CVector builds software to bring real time economic optimization and AI prediction to every energy and manufacturing plant. We integrate real-time data visualization and analytics to help power generation stations, chemical plants, and other critical infrastructure make informed decisions in rapidly changing environments. You'll help create intuitive, robust web apps, machine learning models and backend systems, shaping tools that directly impact industrial operations and energy reliability. Build AI agent systems that automatically foresee upcoming problems and provide possible solutions.

CVector recently raised $5M seed, read more on TechCrunch: https://techcrunch.com/2026/01/26/ai-startup-cvector-raises-...

Full Stack and Backend Software Engineers: We're looking for a passionate Software Engineers comfortable working across our stack (Python, Typescript, React, Supabase, MQTT, TimescaleDB, PostgreSQL, AWS, FastAPI) or someone to specialize in our backend infrastructure.

Senior Research Engineer: Candidates should be experienced with machine learning, and analysis using Python.

Reach out to me at jnapoli+hn@cvector.com

Thunder Compute (YC) | C++ Systems SWE | San Francisco (Onsite) | https://www.thundercompute.com

Thunder Compute is a GPU cloud for developers built on a proprietary software stack of C++ and GoLang. You will solve hard systems problems in production.

Quant dev / HFT SWE experience preferred, team from CitSec, Aquatic, Old Mission, AWS.

Email me: carl@thundercompute.com

Copper Home | Staff Embedded Systems Engineer | ONSITE (Berkeley, CA)

Copper Home (fka Channing Street Copper) builds battery-integrated induction appliances for home electrification — we're making decarbonization accessible by putting energy storage inside everyday products, starting with the stove.

The firmware team is small and owns application firmware, device connectivity, automated testing, manufacturing tools, and an MQTT backend for OTA updates and fleet telemetry.

We're hiring a staff embedded systems engineer focused core firmware architecture on the Charlie induction range.

In this role, you may:

- Own major pieces of our embedded platform and prototypes of future products. - Lead improvements to device connectivity (Wi-Fi, BLE, OTA, provisioning, failure recovery) and energy management. - Evolve fleet management, telemetry, and remote management/update systems with a focus on robustness and cost efficiency at scale. - Mentor engineers through design reviews and day-to-day technical collaboration.

Tech stack: C and Python; FreeRTOS on ESP-IDF; 802.11, BLE, CAN; MQTT; AWS

Salary: $182k–$210k + equity

Questions? Send me an email (<username>@copperhome.com) or reply here.

More details and apply: https://copperhome.com/pages/jobs?gh_jid=4119303007

Spacelift | Remote (Europe) | Full-time | Senior Software Engineer | $80k-$110k+ (can go higher)

We're a VC-funded startup (recently raised $51M Series C) building an infrastructure orchestrator and collaborative management platform for Infrastructure-as-Code – from OpenTofu, Terraform, Terragrunt, CloudFormation, Pulumi, Kubernetes, to Ansible.

On the backend we're using 100% Go with AWS primitives. We're looking for backend developers who like doing DevOps'y stuff sometimes (because in a way it's the spirit of our company), or have experience with the cloud native ecosystem. Ideally you'd have experience working with an IaC tool, i.e. Terraform, Pulumi, Ansible, CloudFormation, Kubernetes, or SaltStack.

Overall we have a deeply technical product, trying to build something customers love to use, and have a lot of happy and satisfied customers. We promise interesting work, the ability to open source parts of the project which don't give us a business advantage, as well as healthy working hours.

If that sounds like fun to you, please apply at https://careers.spacelift.io/jobs/3006934-software-engineer-...

You can find out more about the product we're building at https://spacelift.io and also see our engineering blog for a few technical blog posts of ours: https://spacelift.io/blog/engineering

Alphamatician (alphamatician.com) | Data Pipeline Engineer | Remote | Full-time

We build and maintain alternative data products for institutional investors — structured datasets covering 40,000+ companies globally with up to 15 years of history, delivered via API and SFTP.

Looking for someone to own our data pipelines end-to-end: collection, cleaning, structuring, monitoring, and error resolution. You'd be working directly with the founder.

Stack: PHP (CodeIgniter 4), MySQL (AWS RDS), Python, Node.js. PHP is a hard requirement.

Apply: alphamatician.com/careers

AI x Healthcare Startup | Boston, MA Onsite | Full-time | Early Engineer

We're looking for a backend-leaning fullstack dev. You will be one of the first engineers outside of the founding team. Here is a bit more about us: We're a seed stage AI startup backed by top tier investors. We're on a mission to ensure every patient gets covered for the care they need and every doctor gets paid for the work they do.

We’re building deep, vertically integrated technology systems to solve fundamental problems in US healthcare - the biggest market in the world ($5T). We use AWS, K8s, React, and Rust but there is no requirement to have prior experience with them specifically. We'll teach you!

We are a founding team made up of ex-YC, Amazon, Meta, Microsoft, and Harvard Business School with previous successful exits.

You’ll own entire product areas and be expected to play a true full-stack role, with the ability to go from customer need to end-state product. You’ll work directly with the CTO at the edge of what's possible with LLMs and agentic systems applied to a hard domain. You'll contribute to technical strategy, make real architectural decisions, and write vast amounts of production code with AI first developer workflows. Most importantly, the technology you build will have real impact on real people - clinics staying open, clinicians getting paid, patients getting care.

This is an opportunity to work in a fast paced, high ownership environment while solving real problems in healthcare.

We're happy to share more details on the role in person/on zoom. Please fill out this form if interested!

https://wgwx7h7be0p.typeform.com/to/LV0t8OjI

Luminate | Software Engineer | Onsite Los Angeles, CA | Full Time

Luminate is the entertainment industry’s preeminent data and insights partner, serving as the single source of truth for record labels, film studios, talent agencies, and every part of the music and entertainment ecosystem.

The team's stack is Java w/ Spring, React w/ Typescript, and SQL w/postgres, and snowflake. We use playwright for e2e testing and deploy our infra on AWS.

The team is relatively new (around 3 years old) but is working on an older codebase with plenty of tech debt. Luckily we actually _do_ get time to address our tech debt and take the time to leave our code better than we found it, so it's getting better all the time.

We have an oncall rotation but getting paged is pretty rare.

Apply here: https://luminatedata.com/careers/?gh_jid=4677478005

Please mention Hacker News in your cover letter.

Enveritas (YC S18, non-profit) | Backend Software Engineer | Remote (Global) | https://enveritas.org/jobs/ Enveritas is a 501(c)(3) nonprofit working on sustainability issues facing smallholder coffee farmers. We collect field data in 25+ countries and build systems for analyzing risks in coffee supply chains (including EUDR-related deforestation checks).

* Backend Software Engineer (Python, PostgreSQL/PostGIS, Docker, AWS, Terraform) - $135-$155k — https://enveritas.org/jobs/backend-software-eng/#10d7adef8us (worldwide remote)

Cultivate AI | Senior Software Engineers | Durham, NC | Hybrid (open to remote)

We're building an AI platform for credit unions. A variety of tools (third party integrations + RAG) backed by multiple LLM options, including OLMo, running in our own AWS infrastructure. We're a small team (I'm CTO and our first technical hire) so you'd have real ownership over the AI stack and architecture.

You'd work on retrieval over heterogeneous corpora with citations, agent orchestration and tool calling, model serving infra, and third party API integration. There's a lot of room to experiment with hierarchical retrieval, heavier upfront document processing, and custom agent tooling. Over time we're going to expand into fine tuning, more direct compute management, and some interpretability work.

Stack: Python/FastAPI, React, PostgreSQL/pgvector, AWS/OpenTofu. Looking for someone with a few years of experience building production systems.

Email me at talati@getcultivate.ai if you're interested!

ReadWorks (YC-backed nonprofit - Imagine K12 F'14) | REMOTE (US) | Contract, part-time (~20 hrs/week) | $70–110/hr

ReadWorks is a nonprofit that provides free, research-based reading comprehension resources to 11M+ K–12 students and teachers — focused on under-resourced communities.

We're looking for a Senior Data Engineer to help us design and build a scalable, event-driven data pipeline. You'll be a key technical voice in shaping our data infrastructure — evaluating tradeoffs, establishing patterns, and guiding migration from our legacy system to a modern data architecture.

Stack: Python, AWS Lambda, DynamoDB, S3, SQS, Redshift, EventBridge, AWS CDK

You're a good fit if you have:

- Experience designing event-driven ETL pipelines at scale - Data warehouse experience (Redshift or similar) - Comfort working with and debugging distributed data systems - Nice to have: Ruby (to read the legacy jobs you're replacing)

Apply: Email your details (CV/Resume, Cover Letter, or any other info we should know about you) to engineering at readworks.org

More details about ReadWorks: https://about.readworks.org/ More about the role: https://about.readworks.org/careers.html

flaconi | Germany / Berlin | Full Time | https://www.flaconi.de | e-commerce

flaconi is an online e-commerce for beauty products, founded in 2011 in Berlin. We are active in 12 countries and expanding to more. We're primarily on AWS, use React, Next.js, Vercel for web, Flutter for our mobile app - you will find more details on the job listings.

1. Staff Software Engineer - Frontend - €85.000 - €105.000 EUR - https://grnh.se/kke6q552teu - we will very likely work together. Happy to answer questions.

2. QA Engineer Mobile - €60.000 - €83.000 EUR - https://grnh.se/ad3i2y62teu

AllSpice | https://allspice.io/ | Boston, MA / SF Hybrid or Remote | Full time (US timezones) | Mid/Sr./Principal/Staff | Golang, Vuejs, Rust, Typescript, Python

At AllSpice, we're building the future of hardware development and collaboration, applying modern software design principles to the hardware industry with design review, automated test, and AI (think GitHub + copilot for hardware). AllSpice is unlocking the next generation of smart vehicles, IOT devices, rockets, medical devices, robotics, and much more.

Read more about our latest Series A announcement in TechCrunch (https://techcrunch.com/2025/06/23/allspices-platform-is-the-...)!

We have a highly capable, tight-knit, remote-first team with a flex office in Somerville, MA and SF. We strongly value continuous communication and personal development. See more on our careers page https://allspice.io/careers

We’re hiring primarily for:

Director of Software (Go, typescript, rust) - Hands-on leadership role (60/40% management to IC) spanning our Go, Rust, and Vue/TypeScript stack, where you'll own the technical roadmap, help make key architectural decisions, and build the team shaping the future of hardware development. https://www.allspice.io/careers?ashby_jid=7b9852d3-9aaf-4344...

Director of Infrastructure (Linux, Terraform, Docker, SOC 2) - Own our infrastructure stack, security posture, and compliance programs while building and leading a small, high-impact team. This is a hands-on leadership role (60/40 management to IC) requiring deep AWS and security expertise, experience working with legal counsel and enterprise customers, and the ability to hire and mentor as the team grows. https://www.allspice.io/careers?ashby_jid=88cf1665-04ab-4043...

LLM Platform Engineer (python, Typescript) - Build and own the internal tooling, analytics platforms, and customer-facing applications that power our Generative AI team, spanning evaluation dashboards, data pipelines, and lightweight web apps that surface AI-driven design review insights. This cross-functional role blends Python, TypeScript, and SQL across our LLM stack (Langchain, Pydantic AI, Langfuse) to give both internal teams and customers deep visibility into model performance and outcomes. https://www.allspice.io/careers?ashby_jid=6d5963b2-5c5e-4dec...

Head of Growth - Own and scale one AllSpice's enterprise demand & pipeline generation. https://www.allspice.io/careers?ashby_jid=b1ac9d68-2229-4005...

Tech Stack: Docker, Terraform, GoLang, Rust, Python, Vue, Typescript, Python

Please include any relevant open-source projects or portfolio in your application.

Tavily | DevOps Engineer | NYC | Full-Time

Looking for a k8s, AWS, Helm, Terraform, DevOps nerd to help out the NYC team. We were recently acquired by Nebius, if you love infra reach out to me: Parakh.Jaggi@tavily.com

https://www.tavily.com/careers/jobs