Ploid AI | Barcelona, Spain | HYBRID (preferably on-site) | Founding Engineers | Full-time + Equity

We’re building an AI-first bioinformatics platform to empower plant breeders and life science researchers with agentic AI and LLMs. Backed by pre-seed funding and real demand from biotech and seed companies, we’re looking for versatile founding engineers to help us shape the future of AI in genomics.

What you’ll do:

• Architect and build AI workflows, agentic interfaces, and data pipelines

• Work across the stack: Go, Python, TypeScript

• Contribute to system design, infrastructure (AWS, Docker, Terraform), and devops

• Collaborate closely with scientists and iterate from prototype to product

• Help define our technical culture and roadmap as a core founding member

Nice-to-haves (not all required): LLM integration, RAG systems, gRPC, scientific computing, cloud/on-prem hybrid systems

About us: We’re an early team of engineers and scientists with strong academic and industry backgrounds (ex-BCG, PhD in Plant Biotech, M.Sc. AI). We’re committed to building something impactful, technical, and genuinely useful for life science.

Apply: hello@ploid.ai

More about us: https://ploid.ai

We also consider internship requests from strong student candidates.

Swiss Institute of Tropical & Public Health | ONSITE in Basel (Switzerland) | Software engineer (80-100%) | 70k-100k CHF

We build open-source infrastructure to make pathogen sequencing data more accessible, interpretable, and equitable

We're hiring a software engineer to join the Epidemiology & Virus Evolution (EVE) Group to work at the intersection of two major efforts:

- ARTIC 2: empowering real-time, low-cost sequencing & surveillance [1]

- Pathoplexus: an award-winning open-source platform for sharing viral genomic data based on Loculus [2] - https://pathoplexus.org/

Launched in August 2025, Pathoplexus has already won recognition and awards for its approach to open, FAIR data sharing.[3][4]

Work in a small, international team in a group led by Dr Emma Hodcroft (one of Nature's "Ones to Watch in 2025" [5]) and support data infrastructure used by public health labs and researchers worldwide. This is a chance to make a real impact on global health and data equity.

About you:

- Skilled in: TypeScript, React, Kotlin, Python

- Bonus: Kubernetes, bioinformatics, data pipelines, open-source experience

More details & application here → https://jobs.swisstph.ch/Vacancies/1082/Description/2

[1] https://www.birmingham.ac.uk/news/2025/ambitious-project-to-...

[2] https://github.com/loculus-project/loculus

[3] https://www.science.org/content/article/new-scientist-run-vi...

[4] https://www.nature.com/articles/d41586-024-02864-x

[5] https://www.unibas.ch/en/News-Events/Awards-Honors/Article/N...

GoGoGrandparent (YC S16) | FULLY REMOTE | Full-time | EST timezone | 1 x Tech Lead Engineer + 3 x Senior/Staff Backend/Full-stack/Frontend Engineers | $100k-$160k (partially location-dependent) Build high-quality, robust engineering at the rarest of things - a Silicon Valley startup that is both wholesome AND profitable. We have 8-figure revenue, are YC-backed, and growing fast.

Tech stack (required): Back-end (Node, Typescript, MySQL, REST* / GraphQL), Front-end (Vue.js), deploy (AWS, Docker/K8s)

Minimum 5 years experience (with Node or Vue).

2-stage interview process.

If you want to help older adults and people with disabilities, send your LinkedIn/CV to william@gogograndparent.com (keep it brief) or apply at https://www.ycombinator.com/companies/gogograndparent/jobs

Nutrient | Senior TypeScript SDK Engineer | Full-time | Remote

We're looking for a Senior TypeScript SDK Engineer to join the team responsible for the Nutrient Web SDK.

It is a toolbox for web engineers and application developers who need a painless way to render, edit and process documents. It either runs client-side using WebAssembly or connects to the Nutrient Document Engine. Take a look at its API docs to get an understanding of the scope involved: https://www.nutrient.io/api/web/

More details & application here: https://ats.rippling.com/en-GB/nutrient/jobs/27613cfa-84eb-4...

Nutrient | Senior Internal Tools Engineer | Full-time | Remote

We’re looking for someone who will work on our internal applications - primarily built with Ruby on Rails and Postgres - which power everything from product development and licensing workflows to revenue analysis and operational management across Engineering, Sales, Product, and Finance.

More details & application here: https://ats.rippling.com/en-GB/nutrient/jobs/66934d69-fd40-4...

Onton.com | Sr. Fullstack Engineers and Design Engineers | SF | Hybrid

Join us in pioneering the future of e-commerce search. 1M+ MAU growing rapidly. $10M+ raised from top-tier VCs and individuals with backgrounds from Google, Amazon, OpenAI, Stitch Fix, Whatnot, Stripe, and more.

We're a hard-working team of 6. We have a new office in Jackson Square with a great view that we're looking to fill with other high-performance people!

Tech-wise, it's React/Typescript + Julia, if that's interesting (no worries if you haven't used it). We've also built our own graph db to cope with the scale, and the foundations of a neuro-symbolic AI agent that learns more about the world on every search!

Job posting and more information here → https://careers.onton.com

We read and respond to every application.

Topos Institute | SWE/Senior SWE|Onsite Berkeley/Oxford |Rust/TS

https://topos.institute/contact/

We are a non-profit, independent research institute dedicated to shaping technology for public benefit. We use cutting-edge mathematical research, especially category theory, to develop new computational tools that enable cooperation across difference, with a core strategic focus on reinventing the practice of transdisciplinary scientific modeling.

We’re looking to hire our first full-time software engineer onto the US CatColab team. We are open to hires at both intermediate and senior levels. This is a unique opportunity to shape the design and implementation of an open source software system that draws on cutting-edge research to support collective inquiry for the public benefit.

Goji Labs: Various roles, all REMOTE

We're a fast-growing, strategy-first software studio with multiple openings. Please use "hackernews" as your referral source and I'll flag your CV for priority review with the hiring team.

ROLE: Product Designers | REMOTE (Americas) https://careers.gojilabs.com/32359

ROLE: Ruby on Rails Backend Engineer | REMOTE (Central/Eastern Europe) https://careers.gojilabs.com/32206

ROLE: React/React Native Frontend Engineers | REMOTE (Central/Eastern Europe) https://careers.gojilabs.com/31840

ROLE: Full Stack Typescript Engineer | REMOTE (Central/Eastern Europe) https://careers.gojilabs.com/32205

Connie Health | https://www.conniehealth.com/ | Multiple engineering roles | Hybrid (Boston, MA) | Full-time

Connie Health is a fast-growing healthtech startup on a mission to empower older Americans to make confident, worry-free Medicare plan decisions. We offer a tech-enabled Medicare navigation platform that combines an AI-driven technology with local Medicare experts to help people select optimal healthcare plans and navigate their benefits. Our culture is mission-driven, collaborative, and innovative, as we strive to transform healthcare through data-driven insights and personalized guidance.

We are building a two-sided marketplace, connecting older Americans looking for health insurance with local Medicare agents.

We are looking to fill multiple positions on our rapidly growing engineering team, based out of Boston, MA:

Senior Backend Engineer (Call Infrastructure) | $130,000 - $156,000 + Equity

Responsibilities: Lead the development of our Twilio-based calling + messaging infrastructure, enabling seamless communications between Medicare agents and customers. You must have significant experience with Twilio. Tech Stack: TypeScript + NestJS, Twilio / Five9 / Zoom, Postgres, AWS, Docker + Kubernetes

Lead AI/ML Engineer | $152,000 - $182,000 + equity

Responsibilities: Player-coach role, leading a small team of AI/ML and software engineers to build our top-of-funnel systems. Tech Stack: Python, "traditional" AI/ML model building tools (scikit-learn, PyTorch, XGBoost), open source LLMs, AWS, Aurora/Postgres, Redshift

Senior Backend Engineer | $130,000 - $156,000 + equity

Responsibilities: Build the core backend systems that power our top-of-funnel, such as tracking leads through various channels, integrating with affiliate partner marketplaces, working with AI/ML engineers to build our lead bidding models, dynamically mapping leads to agents, and AI-based lead pre-qualification. Tech Stack: TypeScript + NestJS, Postgres, AWS, Docker + Kubernetes

I am Huan, CTO at Connie Health. If you are interested, please feel free reach out to me directly at with your resume: huan.lai (at) conniehealth.com !

Promptfoo | Senior/Staff Engineers, Security Researchers, GTM & Founding Operators | REMOTE (North America) / Hybrid San Mateo CA | Full-time | https://promptfoo.dev

Promptfoo is the MIT-licensed open-source toolkit 125 000+ developers use to evaluate and secure LLM apps. We just closed an $18.4 M Series A led by Insight Partners with participation from a16z and are scaling a small, senior team of high-agency builders.

Open roles

- Senior / Staff Full-stack Product Engineer (TypeScript + Python)

- Senior / Staff AI Security & Red-Team Engineer

- Solutions Architect / SE (multiple)

- Product Marketing Manager (cyber focus)

- Enterprise Account Executive (Bay Area, multiple)

- Technical Writer

- Developer Advocate

Why join

- Build the definitive AI security stack already used at 30+ Fortune 500s.

- Work in open source.

- Competitive salary, meaningful equity, async-friendly culture of ownership.

How to apply

1. Skim https://github.com/promptfoo/promptfoo then run:

  npx promptfoo@latest init --example getting-started

3. I reply to every thoughtful application and send swag to anyone who tries or contributes to Promptfoo.

Careers page: https://www.promptfoo.dev/careers/

Stellar Science | Hybrid (USA) Albuquerque NM, Washington DC (Tysons VA), Dayton OH | Full time, interns/co-ops | U.S. citizenship required | https://www.stellarscience.com

Company: We're a small scientific software development company that develops custom scientific and engineering analysis applications in domains including: space situational awareness (monitoring the locations, health and status of on-orbit satellites), image simulation, high power microwave systems, modeling and simulation, laser systems modeling, AI/ML including physics-informed neural networks (PINN), human body thermoregulation, computer vision and image processing, high performance computing (HPC), computer aided design (CAD), and more. All exciting applications and no CRUD. We emphasize high quality code and lightweight processes that free software engineers to be productive.

Experience: Other than interns, we currently require a Bachelors degree in physics, engineering, math, computer science, or a related field, plus preferably 3+ years of work experience or a Masters or PhD in lieu of work experience. (Roughly 30% of our staff have PhDs.)

Technologies: Mostly C++23, Qt 6.9, CMake, git, OpenGL, CUDA, Boost, Jenkins. Windows and Linux, msvc/gcc/clang/clangcl. AI/ML and other projects use Python, some use Java or Javascript/Typescript/React.

Apply online at https://www.stellarscience.com/careers/.

Sepal AI | San Francisco, CA (Hybrid) | Full-Time

Things we're building out:

1. Complex RL environments for AI agents across many domains

2. Various tools to streamline eval creation

3. Various tools to streamline hiring operations

Who we've looking for:

1. Python/Typescript full-stack engineer

2. Good to have: infra and container experience

3. Have high ownership, moves fast, likes to work on highly ambiguous problems

4. Wants to work at the frontier of AL eval and RL data

If you're interested or just curious, email me directly at steven at sepalai dot com

BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at kwu@billiontoone.com with your resume or apply through the links below.

- Senior Software Engineer, Frontend: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Senior Bioinformatics Engineer, Prenatal: https://job-boards.greenhouse.io/billiontoone/jobs/449603100...

- Director, AI Engineering: https://job-boards.greenhouse.io/billiontoone/jobs/449575500...

- Director of IT: https://job-boards.greenhouse.io/billiontoone/jobs/455290000...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.

DMI | Principal Full Stack Engineer | Munich, Germany | Full-time | ONSITE

DMI is a bootstrapped startup building the next-gen autonomy platform for defense & aerospace. Join us as Principal Full Stack Engineer to own and shape our product with the CTO.

You'll:

* Build high-performance frontends (Next.js, React, TypeScript)

* Integrate full-stack systems (FastAPI, Python, Rust)

* Optimize CI/CD and DevOps

* Mentor engineers and drive best practices

* Work directly with the CTO to shape product and technical strategy

You have:

* 5+ years building production software (3+ years frontend)

* Deep experience with our stack

* Strong DevOps/testing mindset

* Bonus: Real-time simulation, 3D/geospatial, or defense experience.

Why DMI?

* Product ownership, ESOP (employee stock option)

* A small, expert, high-impact team

* Great Munich office (simulator, BBQ, mountain views), mobility benefits, health and fitness benefits

Other software/ML roles open, just email me.

Interested?

Reach out directly to me (Pau): pgs(a)datamachineintelligence.eu

Two Six Technologies | Reverse Engineer/Vulnerability Researcher | Arlington, VA | ONSITE | Full Time |https://job-boards.greenhouse.io/twosixtechnologies/jobs/547... Two Six Technologies is seeking senior reverse engineers & vulnerability researchers to perform in-depth reverse engineering and exploit development to transition those findings into capabilities. We are looking to hire embedded security researchers with experience in the following categories: firmware reverse engineering, hardware reverse engineering, and Linux/UNIX kernel development. Additional opportunities are available for embedded software engineers, electronic design engineers, digital signal processing engineers, hardware reverse engineers, firmware reverse engineers, and low-level kernel developers looking to enter the security field. We would love to hear from you if you work in the embedded security domain. Preference is for applicants who hold a TS clearance and have the ability to obtain SCI at a minimum. If interested, please reach out to our team @ recruiting@twosixtech.com

Range | Mclean, Virginia - On-site | Full Stack Engineers (Senior/Staff/Principal) | Full-time https://www.range.com/public/careers

We're building the first AI wealth platform and hiring full stack engineers to partner closely with our co-founders and engineering leadership. We're a Series B company with 70 people all passionate about making wealth management better, faster, for every household. We're open to relocating candidates. Email me (tyler at range dot com) if you're interested to learn more.

Stack: Nodejs, Graphql, React, Typescript, AWS Comp: $150 - 250k base + equity

Zigment (https://zigment.ai) | Bangalore / Bengaluru, India | Full-time | ONSITE

Zigment is a customer journey platform. We make it super simple to build AI agents for enterprises.

Why should you join us?

- Small & lean tech team. - See AI in action with enterprises. - Build reliable & scalable AI systems. - Passion for tech & AI. - Access to the latest AI coding & productivity tools.

Roles:

We are hiring for software engineers, forward-deployment, and integration engineers.

For SDE, you will need experience with TS/JS/Python.

Location: Bangalore, India

* We are also accepting interns & new graduates. Feel free to send the email below. *

To apply:

Send your resume to contact@zigment.ai with "Saw HN Post" in the subject line or mentioned in the email.

Our process is speedy. Looking forward to your application.

Littlebird | Senior MLE + Senior Swift Engineers | Remote (global) | https://littlebird.ai/

Littlebird is working on a digital twin for Mac + Android to make anyone more productive, no matter what apps they use. Our team is well funded (~$5M+ seed) and remote-first, and passionate about building a product anyone can use. We're hiring developers with a passion for engineering-led cultures, knowledge graphs, search, contextual understanding, and designing infrastructure that can scale.

Core stack: Typescript, React, Swift, python, Postgres, AWS, some Rust

Apply here:

Senior Applied AI Engineer: https://scarlet-magician-747.notion.site/Senior-AI-ML-Engine...

Senior Swift Engineer: https://scarlet-magician-747.notion.site/Senior-Swift-Engine...

Opsin Security | San Jose / SF Bay Area (Hybrid, 2–3 days on-site) | Full-time | https://opsinsecurity.com/careers

Opsin helps enterprises secure and deploy Enterprise Search/AI systems (e.g. Microsoft Copilot, Google Gemini) responsibly without exposing sensitive data. Venture-backed by Race Capital. You’ll work directly with the founders on a small (<10) person team shipping fast in a huge green-field space.

We are hiring for:

- Senior AI Engineer – 5 + yrs backend + 2 + yrs ML/LLM; Python, SQL, AWS/GCP experience; comp + eq (https://www.opsinsecurity.com/jobs/senior-engineer-ai-engine...)

- Senior Full-Stack Engineer – 4–8 yrs shipping product; React/Next.js + API & DB design + Nest.js; TypeScript, Python a plus; comp + eq (https://www.opsinsecurity.com/jobs/senior-engineer-full-stac...)

- Staff Backend Engineer – 8 + yrs building scalable systems + 2 + yrs technical leadership; architect data-driven services for LLM security; comp + eq (https://www.opsinsecurity.com/jobs/staff-engineer-backend)

- Founding Account Executive – full-cycle sales to CISOs/CIOs; 5 + yrs enterprise SaaS; cybersecurity/Microsoft ecosystem a plus; ~50% travel; comp + eq (https://www.opsinsecurity.com/jobs/founding-account-executiv...)

Tech stack: Python, TypeScript (Nest.js), React (Next.js), Postgres, Azure, modern LLM tooling

How to apply: email your résumé + a short note to careers@opsinsecurity.com with subject “HN – [role]”, or apply on our careers page.

I’m Shay Nehmad, Founding Engineer at the company. Happy to answer questions at shay@opsinsecurity.com or on LinkedIn

Aleph | Senior Software Engineers (frontend, backend, fullstack), Eng Managers | Fully Remote (ET to PT hours) | Full-time | https://www.getaleph.com

Aleph is an AI-native platform for Financial Planning & Analysis (FP&A). We operate in an established software category with a multi-billion market but no clear winner. Our growth has come from product velocity and customer outcomes, not marketing spend, and the results speak for themselves.

We're backed by top VCs (Bain Capital Ventures, Khosla Ventures, YC, Picus Capital), and work with customers like Eight Sleep, Webflow, Turo, Notion, Zapier and others.

Our tech stack: TypeScript, React, Python, Mongo, GCP

See all open positions and more details in https://www.getaleph.com/careers#open-roles

Property Meld | Mid-level and Senior Software Engineers, Product Designer, Product Manager | Full-time | Remote (US & Canada) or Rapid City, SD

Looking for something more meaningful? How about the opportunity to have a direct impact on the property maintenance experience for hundreds of thousands of residents?

Welcome to the future of property maintenance. Property Meld’s vision is to radically improve how the property management industry handles property maintenance. If you’ve ever had a maintenance issue at your housing rental, you know how much of a pain it can be to get it fixed quickly and reliably. It doesn't have to be this way. We're rethinking the entire property maintenance experience from the ground up with two things in mind - first, driving the cost of doing maintenance to the absolute minimum, and second, providing an experience to residents and property owners that makes them want to stay with their property manager. If you are excited about turning something that has historically been a negative experience (maintenance) into a positive experience, we'd love to talk with you.

Stack: Python, Django, Typescript, React, React Native, PostgreSQL

Product Designer: https://property-meld.breezy.hr/p/92a5b2db4b2c-product-desig... Product Manager: https://property-meld.breezy.hr/p/7023bbc73369-product-manag... Engineer postings are not up yet, but you can apply via the email below.

Apply through our career page or you can email us at `tech.jobs at propertymeld.com`