The Tiny Pharma Company | Founding Scientist | London/Zurich
AI+pharma startup. Each person owns a program, from concept to clinic. We hire anyone exceptional, we don't look to fill defined roles.
Founding team are ex-{Cradle, Google, Oxford, ETH}, backgrounds in protein language models, antibody design, JAX scientific ecosystem, neural differential equations.
"RenTech of pharma"
:)
Aristotle (https://www.heyaristotle.com/careers)
Applied AI lab working on the future of education
OneCrew | Multiple Roles | ONSITE / HYBRID | San Francisco, CA
OneCrew is the leading full-business platform system, purpose-built for top asphalt and concrete businesses to win more jobs, scale faster, and run smoother, connecting every team, workflow, and dollar across the business.
We are a Series A company and looking for highly motivated individuals to own their domain and accelerate our growth.
- Software Engineers (x3)
- Product Marketing Manager
Tabula Bio | Founding Machine Learning Scientist | San Francisco, CA | ONSITE | Full-time
We use generative ML to design bacteriophages that treat antibiotic-resistant superbugs (bacterial infections). Using phages in this way is not a new idea. Phages already cure patients in research contexts today. But the process is too slow for the ~50K Americans who die each year from antibiotic-resistant infections. Our models make phage therapy fast, and we’re working with real patients today. Join our ML team. Biology experience is not required; what matters is strong machine learning skills and interest in genome design and saving lives with computer science!
Email me at ammon@tabulabio.com
MixRank (YC S11) | Software Engineers | 100% Remote (Global) | Full-Time
MixRank processes petabytes of data every month through web crawling. Hundreds of customers use our data products, including Google, Amazon, Facebook, Intel, and Adobe, across industries such as finance, recruiting, sales, marketing, and security. We’re a fully remote company with a global footprint across 20+ countries. We’re growing, profitable, employee-owned, and have no dependence on outside funding. Applicants from all geographies and backgrounds are welcome.
We’re looking for passionate individuals for whom programming is not just a job, but something they genuinely love to do. We’re obsessed with computers, programming, big data, databases, compilers, hardware, math, data science, and the internet. Does this sound like you? Please apply to join our team.
Our codebase is friendly to new contributors. You’ll have a fully functional development environment within hours through full automation and will be pushing commits on your first day. Deployments to production happen multiple times per day and finish in under two minutes.Effectively all of our codebase is written in Python, Rust, SQL, JavaScript/TypeScript, and Nix. The core technologies you’ll need familiarity with to be productive are Python, PostgreSQL, Linux, and Git.
We operate at a larger scale than typical startups. We run two datacenters with high-performance servers we’ve built ourselves, capable of handling the volumes of data we process. We’ve implemented our own distributed file system, perform full-scale web crawls, and download and run static analysis on the entire universe of published Android APKs and iOS IPAs.
Unlike a typical startup where you might spend half your time in meetings and the other half fixing Jira tickets, at MixRank you’ll challenge yourself with difficult technical problems that help you grow as an individual. We’re continuously hiring for the positions below; these aren’t singular roles that close once filled. Our philosophy is that the candidate is more important than the position. For each new member of the team, we design a custom role and responsibilities around their interests.
Other companies may create a long list of specific requirements with the expectation that you’ll exactly replace someone on the team or fit a role defined by committee. MixRank is more pragmatic: we first get excited about bringing a unique individual onto the team, then figure out the best way to support their specific talents.
Junior Software Engineer - Remote (Global), Full-Time
We’re looking for remote junior engineers with 0–3 years of professional software experience and 5+ years of curiosity exploring computers, programming, and technical hobby projects.
This is an open-ended entry role with mentorship and diverse opportunities to work across all areas of our product: databases, distributed systems, infrastructure and tooling, data analysis, machine learning, frontend/backend web development, APIs, data mining, data modeling, and more.
To stand out, please highlight what makes you unique: passion for computing, curiosity and side projects, work ethic, niche research, or anything else that shows how you think and build.
Ideally, you’ve already graduated. But if you still have one or more years left of school, please feel free to apply anyway. If you’re the right fit for the team, we’ll figure out a way to accommodate your schedule.
Apply here: https://www.ycombinator.com/companies/mixrank/jobs/Fnwsojk-j
Software Engineer - Remote (Global), Full-Time
We’re hiring generalist software engineers to work on web applications, data mining, machine learning/data science, data transformation/ETL, data modeling, database scaling, infrastructure, DevOps, and more. We’ll tailor the role to the subset of areas that best match your interests.
Beneficial experience includes PostgreSQL, Python, Rust, Linux, TypeScript, Nix, frontend/backend web development, and data mining.
Apply here: https://www.ycombinator.com/companies/mixrank/jobs/RXQspen-s
I’m Kiran, Chief of Staff at MixRank, a fully remote data startup building go-to-market intelligence. We’re US-incorporated but hire globally, and we’re bringing on new teammates to join a fast-moving team with real ownership and impact.
StatusPal | Founding GTM Lead | REMOTE (Europe / EU-overlapping timezone) | Full-time | €55–75k base + uncapped commission (~€100–140k+ OTE) + 1–2.5% founding equity
StatusPal helps engineering and IT teams detect, fix, and communicate incidents — monitoring, incident response, and status pages in one platform. We're small, profitable, and bootstrapped (no VC, no runway clock), with real revenue and customers. What we haven't built yet is a growth engine — that's this role.
We're hiring our first commercial hire to own go-to-market end to end: both marketing/demand (content, SEO, partnerships, paid) and sales (outbound, demos, closing). You'd wake up thinking about how we sell more, lean on AI to punch above your weight, and bring in freelancers or reps when the numbers justify it — running the whole function so it compounds without the founder in the day-to-day. Strong fit if you've done a hands-on 0→few-million at an early-stage B2B SaaS and want real ownership and upside over a big-company base.
Not a fit if you want a finished playbook, warm leads handed to you, or to be purely a marketer or purely a closer — this role owns the whole path.
I'm the founder and will reply to everyone. Full details + apply: https://statuspal.notion.site/Founding-GTM-Lead-39009d5544a7...
Axo Ventures | Senior Software Engineer (Founding Team) | ONSITE: Houston, TX (Sugar Land) | Full-time | $100k–$140k + Founding Equity, adjustable
Clinical software is where a provider's time goes to die. We are building Axo to make the software layer as invisible and ambient as possible, letting clinicians direct 100% of their attention to patients rather than screens.
Our first market is orthotics and prosthetics (O&P), the field designing braces and artificial limbs that restore human mobility and underserved by the tech sector. We're building a foundation designed to eventually scale across thousands of providers and multiple medical specialties.
You’ll join as a founding engineer working directly with myself (Xoogler SWE) and my co-founder (one of the US's best known O&P clinicians), and a new engineer. You will own massive surfaces end-to-end, making the foundational architectural decisions for our entire platform. We have clinics using our suite and already saving hours a day, but we've got a massive pipeline ahead and need your help to build it. And we participate in humanitarian missions to expand prosthetic access in critical parts of the world like Ukraine.
- The Stack: C#/.NET, contract-first gRPC, SolidJS/TypeScript, and PostgreSQL, built with strict domain-driven design and rigorous testing.
- How we work: We have total flexibility on your workflow. Love AI-assisted speed coding? Go for it. Prefer to write by hand because your mental model is faster than prompting? Perfect. We only care about delivering safely and quickly.
- Requirements: Senior-level depth with production systems, a strong habit of domain modeling, and a philosophy that defaults to simplicity. Strong UI/UX experience with an obsession for user simplicity is a must.
To apply, email me directly at jlyman@axoventures.co with a short story about a favorite technical challenge you solved end-to-end. Please put "HN" in the subject line!
Fluidstack | SWE, SRE, Infrastructure, Security, Product, Design | SFO, SEA, NYC, ATX (Onsite)| Full-time | fluidstack.io
Fluidstack is building supercomputers for hyperscalers and frontier labs. We design, construct, and operate gigawatt scale datacenter campuses and then deploy, validate, and operate the GPUs and networking equipment inside.
We're deploying a GW of compute in 2026 in partnership with Anthropic (https://www.anthropic.com/news/anthropic-invests-50-billion-...), and are continuing to scale out capacity in the US.
We're hiring product and engineering across the stack: everything from low level systems programming/firmware on XPUs, automating building controls and datacenter robotics, automating compute and network provisioning and recovery from failures, securing our networks and facilities, and software across dozens of verticals (warehousing, logistics, site selection, commercial operations, talent, legal, etc.)
View hundreds of open roles at fluidstack.io/jobs or send an email to careers at fluidstack dot io
Senior Embedded Software Engineer (Ruggell, Liechtenstein)
Senior Software Engineer (Vienna- Austria, Ruggell - Liechtenstein, Valencia - Spain)
*Y Combinator | Product Engineers | San Francisco (Onsite) | Full-time | https://www.ycombinator.com/software**
YC is hiring Product Engineers to build the future of YC—and increasingly, software for startups everywhere.
We're a team of ~20 engineers building everything from Work at a Startup and Demo Day to investor software, founder tools, AI systems, and new open source projects. We don't have PMs. Engineers talk to users, decide what to build, and ship quickly.
Some of what we've been building:
* New products: GStack rethinks the software stack for an AI-native world. GBrain explores persistent memory and knowledge systems for AI. Paxel and other AI-powered products help founders—and increasingly everyone else—build software and companies faster.
* *Products at scale:* We build and operate Work at a Startup (2M+ candidates, 1000s of early startups), Demo Day, our investor marketplace, SAFE signing, founder CRM, and the software that powers YC itself.
* *Data:* YC has over 20 years of proprietary startup data. We're applying it to how we think about the future of YC's batch, fundraising tools, hiring, recommendations, and entirely new ways to help people start and grow successful companies.
AI has fundamentally changed how we build software, and we're looking for engineers who are already experimenting with coding agents, MCP, LLMs, context engineering, evals, developer tooling, and whatever comes next. Our stack includes Rails, React, Postgres, Python, TypeScript, LLM APIs, and plenty of experimental infrastructure, but we're much more interested in great builders than expertise in any particular framework.
We're in person in San Francisco (Dogpatch). You'll work closely with founders and alongside people like Garry, Jared and Diana, helping define how YC—and startups more broadly—build software in the AI era.
We offer competitive compensation, carry in the YC fund, and a small, high-autonomy engineering team.
Learn more about the team and role at https://www.ycombinator.com/software. If this sounds exciting, I'd love to chat—email me directly at ryan@ycombinator.com.
Aurelius Systems | Defense Tech | San Francisco | ONSITE
We fuse AI, robotics, and directed energy for autonomous cUAS. We build laser weapons to shoot down drones — autonomous, edge-deployed directed energy systems for counter-UAS. VC-backed by General Catalyst, ~12 engineers and ~18 employees total, weekly field tests on our own 400-acre private range in NorCal + Detroit office.
We believe our work has consequential impact. Our mission is to build the most capable, low-cost, highly manufacturable laser defense systems ever created. We operate with extreme dedication to mission, each other, and our values of hard work, stewardship, and clear communication. We value individuals who work hard, are creative, and enjoy building and breaking things.
Open roles (all SF, onsite, full-time + equity):
Business Operations Associate | $90K–$120K Sr. ML Engineer, Perception | $190K–$222K Sr. Robotics Software Engineer, Controls | $140K–$180K Lead, Forward Deployed Engineer (FDE) | $160K–$210K Sr. Robotics Software Engineer | $185K–$235K Electrical Engineer | $130K–$170K
U.S. Persons only (ITAR export control). See all 20 open roles + apply: https://jobs.ashbyhq.com/aureliussystems
Feel free to reach out directly at alfredo@aureliussystems.us — include your resume and the role you're interested in!
Alfredo – Head of Talent @ Aurelius Systems
CLEAR | Senior Fullstack Software Engineers, Engineering Managers, Engineering Directors, Lead Product Managers | NYC Onsite (4-5 days in-office w/ free catered lunch daily) | https://www.clearme.com/
CLEAR is building the secure identity company of the future. Our mission is to make experiences safer and easier—physically and digitally. With more than 38 million Members and a growing network of partners across the world, CLEAR's secure identity platform is transforming the way people live, work, and travel. Whether it’s at the airport, stadium, or throughout your everyday life, CLEAR unlocks the magic of frictionless experiences.
Lantern ( Series A ) | Software Engineers (Python, Full-Stack) | NYC (Onsite) | Full-time | withlantern.com Lantern is building AI-powered revenue intelligence—autonomous agents that turn cold outreach into warm conversations. We detect buying signals across your tech stack, prioritize opportunities, and help B2B sales teams focus on deals that actually close. We're early, agentic-first, and moving fast.
Senior Software Engineer: You'll own complex technical problems end-to-end—translating customer needs into scalable architecture, optimizing AI model efficiency through prompt engineering, and shipping features that directly impact how revenue teams operate. We want bold ideas and people who push boundaries.
Junior Software Engineer: You'll work across our stack (Python, FastAPI, Next.js, React) alongside senior engineers, contributing to real features from day one. Great fit if you're hungry to learn, ship fast, and grow with a startup building cutting-edge agentic systems.
New Grad Software Engineer: Entry point for recent grads excited about AI and agentic systems.
You'll get hands-on experience with our modern data stack (Postgres, ElasticSearch, ClickHouse, DuckDB), Kubernetes/AWS deployment, and Temporal.io, pi.dev, context engineering, workflow orchestration while shipping production code.
This role is based in our Manhattan office (4 days/week in-person). Full health and dental coverage.
IPinfo.io | Data Engineer | REMOTE (Anywhere) | Full-time
IPinfo is a leading provider of IP address data, including geolocation, VPN and residential proxy detection, mobile carrier data, and over 20 other context tags. Our API handles over 120 billion requests per month, and we also license our data for use in many products and services you’ve likely interacted with.
We are looking for a Data Engineer to work on our Places product (https://ipinfo.io/data/places), adding detailed location context to IPs from around the world. This work involves complex BigQuery SQL pipelines to process and clean diverse and messy source datasets. We value simple, readable code and look for subtractive solutions over bloat. We are building something completely new, so the work is very empirical we approach it with an experimental, iterative mindset. Geospatial skills/background is a plus.
Reach out to matt@ipinfo.io if you are interested. Please share a CV and tell us about your background and why this role is interesting to you.
Forecasting Research Institute (FRI) | Data Engineer | REMOTE | Full-time
We're a ~20-person nonprofit doing forecasting research on high-stakes problems, including AI progress, biosecurity, and nuclear risk. We have dozens of active projects that generate forecasting data from surveys, expert panels, and AI systems.
We're looking for our first dedicated data engineer. You'd start alongside an external vendor extending an existing warehouse, then take full ownership. Concretely, the work would involve building ELT pipelines from survey platforms and external sources into a cloud warehouse, maintaining a dimensional model, collaborating with analysts, and overseeing orchestration & monitoring.
You have solid Python + ETL/ELT, strong SQL and dimensional modeling, cloud warehouse experience. Nice to have: dbt/Airflow/Dagster, prior SWE work, interest in forecasting. Apply even if you don't tick every box!
Conditions:
- 100% Remote (worldwide) / Remote (global)
- 30 days PTO, health insurance contribution
- $75k–$130k, depending on experience
- 3 team retreats/year
Hiring process: short work test → paid 10-hour test → a few interviews.
Apply at https://forecastingresearch.org/careers/data-engineer
Distru (https://www.distru.com) | Senior Software Engineer | USA | REMOTE (Americas & Europe) | Full-Time
Distru is the #1 ERP in the cannabis industry, $3B in annual sales flows through our platform, and most of the top cannabis brands and distributors in the US run their entire operation on us to stay compliant.
We're profitable, stable, and growing — no runway anxiety, and we're reinvesting into new product lines. We're an intrinsically motivated team that works without ego, is constantly learning, and genuinely cares about our people (5/5 on Glassdoor).
Distru is at an inflection point. We have deep market penetration in cannabis ERP, a new commerce layer (Distru Commerce — a B2B wholesale marketplace) live and growing, and a roadmap with a growing AI component. Our live AI Order Agent already lets buyers submit orders in any format from any source, killing manual data entry, the first of many bets on using AI to strip the repetitive heavy lifting out of running an ERP.
The role: You'll own mission-critical, full-stack features end to end — planning, design, implementation, testing — across every part of the product. You might work on AI-native features (order/purchase intake, smart product matching, systems that learn from user feedback), Distru Commerce storefronts and ordering, manufacturing and distribution workflows, cultivation mobile tools for the floor, or compliance integrations with state systems like Metrc. It's a high-ownership role: you'll partner directly with product, design, support, and our C-suite, and you'll get customers writing you personal "thank you" emails.
Stack: React + TypeScript · Elixir/Phoenix + GraphQL · PostgreSQL · React Native
Apply: https://jobs.lever.co/distru/5cc536aa-86cc-4164-bfc8-8f19ce2...
Grafana Labs | Senior/Staff Software Engineer - AI / Agentic apps | 100% Remote (US + Canada) |
Im the hiring manager - some of the product highlights under the team's scope: - Grafana Assistant: the actually useful AI assistant that helps you do everything in Grafana; it works everywhere - even in OSS! - Investigations: background agents for investigating issues - Grafana Cloud CLI (GCX): CLI covering the entire surface of Grafana Cloud/OSS APIs; plays great with Claude Code/Codex/Cursor and the Assistant - AI Observability: helps you build useful agents and then lets you monitor, eval and improve how they behave - O11y Bench: compare agents' performance across a range of observability/SRE tasks
Our pace of development and innovation is RAPID - the AI Observability product went from being the winning hackathon project to public preview in 6 weeks. We are at the cutting edge here - we are experimenting with autonomous (but safe) SREs, an agentic platform, improving agentic dev experience with o11y insights, fine-tuned LLMs for specific tasks, and more.
We are looking for highly ambitious engineers who have a great sense of ownership, are all-in on agentic development, and have previously built and operated systems at scale. We are all full-stack and love initiative- we would love to talk with you _especially_ if you built something out in the open!
Canada JD: https://job-boards.greenhouse.io/grafanalabs/jobs/6100673004 US JD: https://job-boards.greenhouse.io/grafanalabs/jobs/6100672004
also, please free to get in touch with me directly via https://www.linkedin.com/in/artur-wierzbicki/ or first.last@grafana.com
Enveritas (YC S18, non-profit) | Backend Software Engineer | Remote (Global) | https://enveritas.org/jobs/
Enveritas is a 501(c)(3) nonprofit working on sustainability issues facing smallholder coffee farmers. We collect field data in 30+ countries and build systems for analyzing risks in coffee, cocoa, and tea supply chains (including EUDR-related deforestation checks).
* Backend Software Engineer (Python, PostgreSQL/PostGIS, Docker, AWS, Terraform) - $135-$155k -https://enveritas.org/jobs/backend-software-eng/#10d7adef8us (worldwide remote)
Yardstik | Senior Software Engineer | Minneapolis, MN | $120,000 - $200,000
Yardstik is a start-up software company with a mission of building trust and safety into the Internet Economy. The world of background screening, certification, and training has lacked innovation and we’re here to change that for our customers. Our enterprise-class technology allows us to provide a right-fit solution for our customers realistic for any platform, in any industry. Join us in our efforts to protect organizations and their people.
We are honored to have recently been named a MSPBJ Best Place to Work for the sixth year in a row and named to Newsweek’s America’s Greatest Startup Workplaces. Come be part of our amazing culture and join an environment where you can see and feel the impact of your work every day.
This position will be part of a team focused on Yardstik's core background check business. The team's mission is to push beyond existing products and features to create a new category for Yardstik.
You are the right candidate if you are an experienced engineer with a passion for writing quality software who strives to remain up to date with the latest development practices and are ready and eager to hit the ground running in a collaborative environment.
Apply at https://app.trinethire.com/companies/135023-yardstik/jobs/12... and continue to watch our careers page as we are growing!
fractile.ai - AI hardware, backed by Founders Fund - London (UK) - Onsite
ABOUT FRACTILE Fractile was founded in 2022 on the bet that, eventually, the world’s most capable AI systems would be limited in their impact by the amount of time they take to produce useful outputs. We bet everything on the logical conclusion: that the only way to truly unlock this latent value, to make speed viable at scale, was to radically re-invent the hardware that we run our frontier AI models on. Ever since, we have been building chips and systems that tackle this problem: how to generate output at thousands of tokens per second, while handling the complexity and capacity challenges of operating large models at very long contexts.
We’ve recently raised $220M from Founders Fund and Accel and the most important work lies ahead. Come and join the mission!
THE ROLE As a Software Engineer you will be a core part of our technical team working alongside the hardware, software and research teams to solve cutting-edge problems in AI hardware, ranging from verification to simulation, alongside the best of the best (DeepMind, Apple, Meta…).
ABOUT YOU 1) You have exceptional ability. We look for pivotal IC contributions that solved the hardest problems in big tech companies or hedge funds; competitive hackathons, International Olympiad medals, or rank highly in other competitions like advent of code
2. You are a top engineer. We are not looking for specific languages or technologies - you will be a master of several, you excel at algorithmic skills and solving problems logically in any programming language. And you are very comfortable learning new skills on the fly. You like to work in Python and C++
3. It’s likely you have several years of professional experience, but we will make exceptions for the right candidate
4. You want to work with the best. And you are excited to work in chips, solving the hardest problems at the frontier of AI
WHAT WE OFFER 1. Competitive compensation and meaningful equity 2. A very cool office with London's best views 3. Private medical insurance and pension benefits
If this sounds like you, ping carmen@fractile.ai