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Prolific Machines | Senior Software Platform Engineer | On-site mostly (Emeryville, CA) | Full-time | $160k–$210k + equity
We use light to control how living cells produce therapeutic proteins — optogenetic cell engineering, custom illumination hardware, and real-time ML bioprocess control — to drive down cost and scale up production of next-generation therapies.
With our technology scaling from the lab to the real world of biomanufacturing, we're now hiring a foundational software engineer to build the platform tying together our hardware, firmware, cloud, and internal tooling — high ownership over architecture and direction. This is a systems role across the hardware/software boundary (not web/SaaS), working directly with embedded, mechanical, data, and even bioprocess engineers.
Looking for: strong systems thinking; Python + one of TS/Go/Rust; cloud-connected services; comfort interfacing and debugging software against hardware (serial, TCP/IP); Linux. MS + 5 yrs or BS + 7 yrs. Bonus: Industrial IoT (MQTT Sparkplug B, OPC UA, SCADA/MES), regulated-industry data integrity (21 CFR Part 11, GAMP 5), or embedded C/C++.
Apply: https://jobs.lever.co/prolific-machines/6d71f9d0-7248-4449-8...
Happy to answer questions: matt dot fay at prolific dash machines dot com.
focal vc | Head of Tech & AI | Remote/Onsite/Hybrid (US) | Includes meaningful carry
full description: hiring.focal.vc
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focal leads inception rounds in exceptional technical founders - often before the company is obvious, before consensus forms, before datasets show a trace.
We're now hiring a founding technical leader to build the software, data, and AI systems that help us see earlier, decide better, act faster, and compound what we learn across every opportunity and portfolio company.
This is NOT an internal AI tools role. This IS a founder role. You own the proprietary intelligence layer - the system that shapes how we source, decide, support, learn, and execute.
We're looking for someone we'd back as a technical founder, but whose obsession is building the machine behind many companies rather than just one.
Details: - Carry: In Fund II and every future fund you're part of. Startup equity is one bet on one outcome. Carry is participation in every company we back, across every fund, for as long as you're here. Grants layer over time and your upside compounds. Exact % shared with qualified finalists. - Cash comp: Commensurate with experience and impact (~$175k-$250k base) - Additional benefits: 100% paid healthcare, 401(k), 6 weeks PTO, 3 months paid parental leave - Budget: For tools, compute, office needs, and experimentation - Setup: High trust, low process. You have wide autonomy over how you work, we care first and foremost about impact.
Apply: Send hiring@focal.vc your LinkedIn (and X if you have it) along with the thing you've built in recent months you're most proud of and why. We look for evidence of taste, systems thinking, and judgment.
Full post: hiring.focal.vc
Karhuno Group / https://DearHiringManager.io | Full-Stack Developer | REMOTE (US only) | Full-time
DearHiringManager.io is an early-stage SaaS product that helps job seekers find the real decision-maker behind a job opening.
A user pastes a job post URL, and the system identifies the likely future manager or team lead, plus their work email and LinkedIn profile.
We are looking for a full-stack developer to help us improve and grow the product.
You will work on: * The web app * Job post parsing and company data * Logic for identifying likely decision-makers * Contact enrichment API integrations * AI prompts and structured outputs * User flows, credits, payments, saved results, and reliability
Stack/experience: * JavaScript or TypeScript * React, Next.js, or similar * Backend APIs and databases * Third-party API integrations * SaaS basics: auth, payments, limits * Nice to have: OpenAI APIs, Supabase, Vercel, Stripe, Resend, scraping/enrichment tools, recruiting or job board products
This is a hands-on role on a live early-stage product with real users. You will work directly with the founder and have a lot of ownership.
Apply: lars@dearhiringmanager.io
Please send a short note about yourself and links to things you have built.
LabAMI | Full-Stack Engineer | Remote (US) | Equity Only | Full-time | https://labami.ai
Help Us Shape the Future of Music Education
LabAMI’s mission is to harness technology to make learning music more accessible, intuitive, and meaningful for everyone. We empower teachers to expand their impact, help students chart inspiring learning journeys, and aim to connect a global community of musicians, educators, and enthusiasts.
We're looking for a software engineer interested in developing scalable and polished full-stack applications. We've started with a cross-platform mobile and are planning expansions to desktop and web.
What We’re Looking For
- Strong skills in at least one programming language.
- Passion for developing tools for music education.
- Ownership mindset and ability to thrive in a collaborative, fast-paced, early-stage environment
- Excited to work with Elixir, Flutter, and Rust.
This is a remote, equity-only role with a mission-driven, flexible team that cares deeply about music and technology.
Apply here! https://forms.gle/jRQCwbp1nz9xk5TPA
I am looking for someone who can help us build the ecosystem or an affiliate program for www.commudle.com in the USA. Can reach out directly to me with reference to this post at arpan[at]commudle[dot]com. The relevant designation names include growth hacker, B2B marketing expert, and can even lead to head of marketing.
Weave Bio | Full time | https://weave.bio/careers | Series A
Weave Bio has developed an AI-native platform to help research and discovery scientists get through the FDA regulatory submissions process 97% faster!
- Senior Backend Engineer (python/django)
- Staff Backend Engineer (python/django)
- Senior Customer Success Manager (B2B SaaS)
- Director of Sales (player-coach for 4+ Account Executives)
Please apply here: https://job-boards.greenhouse.io/weave
San Francisco (SF), Hybrid/Onsite 3 days/week (Tues/Wed/Thurs)
Felt Clinic (https://feltclinic.com) | Web Engineer | Remote (US Only) | Full-time | $180k-$200k
Felt Clinic is building the first embedded care SDK for health apps. Our mission is to make access to a doctor simple and secure inside any mobile application. We want teams to stop worrying about provider contracting and focus on building awesome experiences. We're looking for a NextJS Engineer to help us scale our platform. You’ll be developing powerful SDKs and APIs, integrating real-time communication tools, and shaping next-generation digital health experiences.
Tech Stack:
- Mobile: SwiftUI (iOS), Kotlin (Android), Ionic
- Web: Next.js, Turborepo, TypeScript
- Communication: WebRTC
What sets exceptional candidates apart:
- Hands-on experience working on mobile platforms (Swift/Kotlin)
- Expert with Next.js and RSC
- Stoked about healthcare experiences
- Deep expertise in full-stack product development
Felt has three name-brand Apps actively using our SDKs and anticipating approximately $10m ARR by late 2026. We’re backed by leading investors including 1984, Scrum Ventures, and Tau Ventures. Join us as we scale to build next-gen HealthKit on steroids.
EggAI | Tech Lead, AI Engineer, Senior/Lead Platform Engineer/devops | REMOTE (EU, Switzerland, Norway) | Full-time or Contract Multiple roles open.
We are a small boutique consultancy and are quite experienced. A lot of us have extensive consultant experience. You will join a small, highly skilled remote team of engineers and transformation practitioners working at the forefront of enterprise AI.
We use AI for both development and in our solutions. We are looking for engineers that are critical thinkers, understand the limitations of AI but also where it can have a positive impact.
Apply at: https://grnh.se/wr97lgu2teu
Our website: https://egg-ai.com/
G-Research | London, UK | On-site | https://www.gresearch.com/
G-Research is a quantitative research and technology firm. We build the platforms, tools and infrastructure that enable our researchers to explore complex questions in financial markets at scale.
Our engineers work on challenging problems spanning machine learning, distributed systems, high-performance computing and large-scale data processing.
We're currently hiring:
- Performance Engineering Manager: https://www.gresearch.com/vacancies/performance-engineering-...
- ML Performance Engineer: https://www.gresearch.com/vacancies/machine-learning-perform...
- Quant Developer: https://www.gresearch.com/vacancies/quantitative-developer/
- Machine Learning Engineer: https://www.gresearch.com/vacancies/machine-learning-enginee...
- Production Software Engineer: https://www.gresearch.com/vacancies/production-software-engi...
Attendi | Senior Mobile Engineer | Amsterdam, Netherlands | ONSITE (hybrid) | Full-time (80–100%, ~4–5 days/week) | Visa sponsorship + 30% ruling possible
Company: Healthcare professionals spend too much time on admin when they should be delivering care. Attendi is building the Dutch healthcare sector's voice-enabled (digital) notepad: an intuitive tool for capturing and structuring medical data at the point of care. We have product-market fit and are scaling from ~100 healthcare organisations to 10x our userbase over the coming year. Our first native Android and iOS apps are already released and in daily use (https://apps.apple.com/nl/app/attendi/id6757230193), and we're looking for someone to lead their development.
Role: As our senior mobile engineer you'll own these apps end to end: building and maintaining the native Android and iOS clients, plus our open-source microphone SDKs (https://github.com/attenditechnology/attendi-android and https://github.com/attenditechnology/attendi-ios).
Stack: Kotlin (Jetpack Compose) on Android, Swift (SwiftUI) on iOS.
Apply: https://attendi.recruitee.com/o/senior-native-androidios-mob... - or email omar [at] attendi [dot] nl with something you've shipped. Mention HN.
Quin | Founding Engineer (CTO for the right person) | REMOTE (US), preference for Bay Area (tech), Chicago (consumer), or NYC (finance) | Full-time
Quin is an agentic platform to (finally!) solve personal finance for people. It is a consumer-focused company.
I spent 13 years in private banking and have been working on Quin alone for about 15 months. I built 6 different prototypes to test different approaches. I've spent the last few weeks working with testers on the latest version and solidifying GTM. I need someone to take over engineering with a focus on building the backend and data layers that will support our agentic approach to personal finance.
Georgetown. UCLA (MBA). Ex-JPMorgan.
Traction: Prototype with testers
The role: You're the first engineering hire. This is about shipping the workflows that will become the product that users will trust and the data layer that can support an agent in the future.
You'll own backend architecture decisions from day one. Contract-first development (TypeScript contracts repo as source of truth), FastAPI, Supabase/Postgres, Groq for LLM inference. The stack is clean and the codebase is small.
Who I'm looking for: A full-stack engineer with a preference for backend. 5+ years backend engineering; Python / FastAPI preferred. Strong data modeling instincts — you've designed schemas that had to scale. Experience with multi-tenant data architectures. Comfort operating without process. Finance domain familiarity a plus, not a requirement. Comfort and experience using AI tools and incorporating new ideas quickly.
For the right person, this is an opportunity to take a CTO/co-founder role and define the full technical path.
Comp: Salary post-raise and meaningful equity. TBH, finding this role (either version) will be important for rasisng capital given that I do not have a technical background and fintech is complicated by regulations. I'm ok with part-time in the meantime if that's what it requires.
Email quin@iamquin.ai with the primary reason this interests you and the top two reasons why you should be considered (don't worry about a resume at this point).
Founding Senior (AI/Software) Engineer | NYC | https://www.l2labs.ai/
L2 Labs is a brand new applied AI lab building machine intelligence for data integration and interoperability. We're fast growing: we closed a pre-seed funding round, established partnerships with Cornell and NYU, and secured a large enterprise customer in less than 3 months. We are a team of hard-working researchers and engineers who are obsessive about intricate, greenfield data problems - we love whiteboarding, spinning up experiments, ordering pizza, and suddenly it’s 2am and we've actually solved something. We build impactful products + publish in A* research venues.
We are currently seeking Founding Senior SWEs, with very meaningful upside in the form of a generous equity package + working alongside skilled engineers and PhDs from top universities. To learn more/reach out, email me at andrew@l2abs.ai.
REMOTE
PermitFlow (YC W22) | Staff, Fullstack & Frontend Software Engineers | New York, NY | ONSITE | Full-time | https://permitflow.com PermitFlow’s mission is to streamline and simplify construction permitting in the $1.6 trillion United States construction market. Our software reduces time to permit, supporting permitting end-to-end including permit research, application preparation, submission, and monitoring.
We recently raised a $54M Series B led by Accel with participation from Kleiner Perkins, Felicis, Altos Ventures, and YC.
Permitting is a challenging yet interesting problem; thousands of municipalities across the United States have their own processes and requirements - many which are continually updating. Software, AI, and LLMs provide an exciting opportunity for us to reason at scale and distill a nuanced and localized permitting process into a standard and streamlined experience for our customers.
We're looking for customer-obsessed, ambitious, and hard-working teammates who are excited about solving a real-world problem with technology at its helm.
NYC Onsite Roles | apply at: https://jobs.ashbyhq.com/permitflow?departmentId=d33195eb-89...
1. Staff Software Engineer - $200K-275K + equity
2. Fullstack Software Engineer - $125-245K + equity
3. Senior Frontend Engineer - $125K-245K + equity
Comvex | Full Time | Multiple Roles | REMOTE (US, South America)
We're a healthcare revenue cycle management (RCM) technology company looking for our first set of full hires to help us build out our technology pipeline. RCM experience for these roles is a MUST.
The Roles:
Forward Deployment Engineer * EHR Integrations * Senior-level * 7+ years * 150-190K
Design and build EHR integrations across customer EHR platforms (e.x. Epic, Athena, ModMed, eClinicalWorks) via API (FHIR, HL7) or RPA/computer vision based integrations. Work directly with medical billing teams automate workflows and roll out deployments. Join discovery calls, onboarding sessions, technical troubleshooting, rollout and go live discussions. You MUST have EHR integration experience for this role.
Platform Engineer * AWS/Data Pipeline Experience * Senior-level * 6+ years * 140K-160K
Design, build, and expand our core task pipeline, and data infrastructure platform. Work with healthcare billing data (837, 835, 270/271), HL7 and FHIR data. Experience with data engineering and/or infrastructure engineering with some DevOps experience and a solid understanding of RCM processes is the type of person we're looking for here. We're AWS based cloud infra heavy leveraging a number of Python based Lambdas.
Full Stack Web Developer * Django, Next, Node * Mid-level * 4+ years * 110K-130K
A focus on automation of workflows and integration with 3rd party APIs. Hands-on experience with Playwright in production environments. Direct familiarity with clearinghouses (Change Healthcare, Availity, Waystar, or similar) and insurance payer portals. Full stack web dev experience building out reporting and dashboards mainly customer/internal.
IT Specialist * AWS Cloud + On Prem * Senior-level * 10+ years * 90-110K
Deep familiarity with Teams and Microsoft based cloud and on prem software. Hands-on AWS experience in practical administration of production cloud deployments. Strong troubleshooting instincts and comfort working independently. The ability to role up your sleeves and learn the best ways to configure, monitor and manage any application or service.
We just got our funding finalized and it's time to take our POC from a pitch into a full product. All roles are fully remote and open to anywhere in the USA or South America. Rates are dependent on experience and location.
Stack is mainly the same for all roles (Python, Django, OpenCV, Node, React, Claude). RCM experience for most roles is a must. Education needed is flexible. If you've got the proof to back up you can do the work that's what I'm interested in. Hours are flexible for most roles (forward deployment engineer will need to be available for most of a standard day's EST hours).
Email me at peter.lever@comvex.ai with what role you'd like to apply for and your CV if you're interested and we'll go from there.
Memora | Founding Engineer | REMOTE (EU, 4h overlap with CET) | Full-time | Senior IC salary + meaningful founding equity
We're a 5-person startup building software for cemetery & public-records management: municipalities managing data for real families. Broad, hands-on IC role with real product and infra ownership.
Stack: NestJS/TypeScript, PostgreSQL + PostGIS, MikroORM, Inngest · React + TanStack Query, MapLibre + PMTiles · React Native + Expo · AWS (ECS Fargate, RDS, S3, Bedrock, WAF) + Terraform · Grafana/Sentry · QGIS/GeoPackage geospatial.
You: 8+ yrs production, full-stack TS, owned a Terraform/AWS stack (not just consumed one), strong relational DB fundamentals, comfortable with no playbook. Bonus: PostGIS, RN/Expo, RLS/multi-tenancy, LLM, B2B/B2G.
We lean hard on AI tooling and expect you to: but the bar is human-reviewed, well-tested code; "the model said it worked" isn't a defence. Remote by design, quarterly offsites.
Apply here: https://zrec.eu/E0KZN
vvd | Design Engineer | Remote (work from anywhere) | Full-time | React, TypeScript, Next.js https://vvd.world
We’re building tools for storytellers, worldbuilders, writers, and creators.
We’re looking for a Design Engineer who can design and build polished product experiences end-to-end. You should care deeply about taste, interaction, motion, and frontend craft, but also understand enough about APIs, auth, and data flow to avoid getting blocked.
We’re AI-native, but not trying to replace human creativity. We use tools like Cursor and Claude Code as leverage to move faster while keeping a high quality bar.
Strong fit if you’ve shipped real things, can go from rough idea to polished implementation without waiting for perfect specs, and have built interfaces that feel good, not just functional.
Apply: https://jobs.ashbyhq.com/vvd/c56cc77f-1ac1-4e31-9281-b7d0121...
Full Stack Engineer | Lucknow, India | Remote
Looking for: Full-time SDE roles at early-stage startups.
Tech Stack: TypeScript, Next.js, Node.js, PostgreSQL, Supabase, React.
About me: Final year CS undergrad currently interning at DentalScan (US). I am a "full-stack engineer who ships."
Recent Projects:
VibeDraw: AI sketch-to-website platform with a runtime React compiler and 3-tier AI pipeline.
AI Voice Booking Agent: Handles 200+ req/hr.
Inventory SaaS: Built with NLP querying capabilities.
Portfolio: https://portfolio-phi-red-69.vercel.app/ Email: ashutoshpandey23june2005@gmail.com
Estuary | US-Based / Remote | Full-time – https://estuary.dev/
Estuary is a VC-backed, post–Series A startup powering right-time data replication and transform — from sub-second CDC replication to terabyte-scale OLAP data flows. We’re open-source, developer-first, and focused on making data movement radically simpler across both our Platform and Applications layers.
We’re hiring for:
Senior Systems Engineer — Capture & Materializations Design and build high-performance connectors that move data in and out of Estuary in real time. Work across APIs, databases, and streaming systems to ensure correctness, reliability, and scalability. This role is deeply systems-oriented, with a focus on data plane execution. Go and Rust are core to our stack.
Senior Systems Engineer — Control & Data Plane Own core infrastructure that orchestrates and powers Estuary’s runtime, from control plane services to distributed data processing systems. Tackle challenges in scaling, fault tolerance, and performance across a globally distributed system. Strong backend fundamentals required; Go and Rust experience preferred.
Senior Front-End Engineer Build highly interactive observability and data-flow experiences for the Estuary platform. Design and develop real-time visualizations of distributed data pipelines, metrics, and system health using React and TypeScript. We’re looking for engineers with deep front-end expertise, strong performance instincts, and experience building complex data visualization or developer-focused products.
Product Manager Own product areas end-to-end, working closely with engineering and design to shape the roadmap and deliver a great developer experience. Engage with users, translate real-world use cases into product decisions, and help define how modern data infrastructure should feel to build with.
Technical Product Marketing Manager Founding product marketing hire working closely with Estuary’s Head of Marketing and Developer Relations team. Help shape how we position and communicate the platform to technical audiences through product launches, messaging, technical content, demos, customer stories, and developer-facing campaigns.
What we’re looking for: Engineers who care about building reliable, maintainable systems and enjoy working with complex APIs and data flows. We value curiosity, clear communication, and a willingness to learn.
Bonus points for experience with CDC tools, open source contributions, or fast-paced startups.
To apply: Email your resume to careers@estuary.dev