Protillion Biosciences | full-time | San Diego (Carlsbad) | On Site | $150-200k

We're a small, late Series A team generating massive datasets of antibody-protein interactions to engineer next-generation therapeutics. Looking for talented software engineers to lead efforts in drug design and build iterative end-to-end automated discovery workflows. Background in AI/ML required and bioinformatics and protein engineering/design a plus.

What makes our platform unique:

- We're generating massive quantitative datasets on 10^5-10^6 antibody-protein interactions at once. This is about 3 OOM higher than competing platforms.

- We've closed the loop between protein design and data collection with our own custom hardware. We use this to test in-house designed massive antibody libraries with every cycle taking as little as two weeks

- We're a drug discovery company - using our technology to create therapeutics with properties exquisitely tuned to the biological context and needs of patients.

Interested in practical applications of ML to address unmet patient needs in the fastest-growing field of new therapeutics?

Application: https://job-boards.greenhouse.io/protillionbiosciences/jobs/...

Website: https://protillion.com/

Collective Intelligence Project | Lead Product Engineer | Remote (US time zones, PST preferred) | $150k | https://www.cip.org/careers/productengineer

The Collective Intelligence Project (http://www.cip.org) builds platforms that allow large groups of people to participate in decisions about AI systems. In short, we’re building the democratic infrastructure for AI.

We partner with AI labs and governments to evaluate frontier models on questions automated benchmarks can’t capture — e.g. whether models respond safely to mental health crises, provide reliable legal advice across languages, or exhibit political bias.

We’re looking for a Lead Product Engineer to build infrastructure behind this work.

You’ll work on: - evaluation platforms used by AI labs and policymakers - systems for collecting and aggregating large-scale human judgment data - interfaces that help policymakers interpret evaluation results - infrastructure for large-scale public deliberation about AI

Stack currently includes: TypeScript, React/Next.js, Postgres, Supabase, Vercel. You’ll have significant ownership over architecture and product direction. We’re hoping candidates are already familiar with Claude Code / Codex / Cursor, and are excited about using AI as a force amplifier across projects.

If you're interested in building infrastructure for democratic AI governance, we'd love to talk.

Apply here: https://www.cip.org/careers/productengineer

DeepL | Full-time | London, Berlin/Munich, New York | HYBRID

At DeepL, we're building intelligent, trusted AI for language and beyond.

Hiring for technical roles:

Engineering (21 roles): Software Engineers (Backend, Full-Stack, API, Voice), Data Scientists, Analytics Engineers, Security, Platform, Agentic AI

Research (8 roles): Research Scientists, Research Engineers (HPC, Data, Tooling), Voice specialists

Product (3 roles): Product Managers, Product Designers

All positions: https://jobs.ashbyhq.com/DeepL

Me: https://www.linkedin.com/in/steven-syrek/

Digital Health Strategies | Full Stack Product Engineer (Ruby, JavaScript) | REMOTE (USA or Canada); Washington, DC; NYC; Vancouver, BC; | https://digitalhealthstrategies.com | $140k - $220k

We are a series B health tech and data company building software for large non-profit health systems to grow patient volumes, connect patients with the care they need, and raise money from grateful patients.

We offer the industry leading grateful patient web app that allows health systems stand up highly integrated web sites quickly and easily to collect stories and feed donor pipeline development.

We're a 30-person team, spread between Washington, DC, New York City, Philadelphia, and Vancouver, BC. We reached $4MM+ annual revenue before raising any outside capital.

We're looking for a mid to senior full stack software engineer generalist who is eager to manage their own product, likes to build quickly, and is focused on understanding the customer and solving their problems. You will have ownership and autonomy with minimal meetings. We use ruby, rails, javascript, postgres, aws, docker.

I'm Arif - reach out if this sounds interesting arif@digitalhealthstrategies.com.

Adalat AI | https://www.adalat.ai | Remote (India) | Go, React, Next.js, k8s We're Hiring at Adalat AI: Join Us in Building the Future of Justice

Adalat AI is on a mission to transform India’s judicial system with cutting-edge AI — reimagining courtroom workflows from transcription to summarization, just as UPI transformed payments and Aadhaar revolutionized identity verification. Deployed across 10 states and recently launched at the Delhi High Court, our platform is backed by global foundations and built by a team with roots at Harvard, Oxford, MIT, and IIIT-Hyderabad.

Roles:

- 2 X Fullstack Engineer (5+ YOE) – Own end-to-end feature delivery across React/Next.js, Go services, with Postgres as your database: https://airtable.com/appfFN4xrE3q3g5pX/pagosm1T5frIgr7yO/for...

- Full stack Lead Engineer (10+ YOE) - Own technical leadership, mentor engineers, set technical roadmap of several of our products: https://airtable.com/appfFN4xrE3q3g5pX/pagDHNefjvTf2QAq3/for...

- Senior SRE (10+ YOE) - Set up high-availability Kubernetes clusters, manage complex deployments with ArgoCD, and ensure reliability for a system processing sensitive, real-time data: https://airtable.com/appfFN4xrE3q3g5pX/pagfFeSwSKsPTWAGh/for...

Why Adalat AI?

- Mission-driven: Your work has real-world impact—helping untangle India’s court backlog, improving access to justice for millions.

- Remote-first: Work from anywhere.

- Unlimited PTO: Yes, seriously.

- Unique environment: Co-design with judges, legal experts, and researchers. Publish, learn, grow. We value tech, law, and impact equally.

Careforce AI (aka Helpcare) | Senior Fullstack Engineer | REMOTE (US) Location: Remote (US) Remote: Yes (US Only) Willing to relocate: No Technologies: Python, FastAPI, React, Supabase, GCP, LLMs Résumé/CV: https://bookface.ycombinator.com/company/30124/jobs/78672 Email: Apply via link above

Description: Careforce AI is building autonomous AI agents that eliminate the manual administrative burden in healthcare (fax machines, scheduling, calling). We find, call, and schedule patients, breaking interoperability barriers that have plagued the industry for 40 years. We are a well-funded, YC-backed company with massive customer demand.

We are looking for a Senior Fullstack Engineer to be a foundational member of our small, ambitious team. You will have significant ownership working across the stack to build and scale the core of our AI agent platform. We are looking for builders with 5+ years of experience, preferably with an early-stage startup background (Pre-seed to Series A).

Duolingo | Full-time | Multiple roles | $177K-$240K for NY roles | NY and London | Hybrid

Our mission is to develop the best education in the world and make it universally accessible. Our culture is eng-driven, friendly, and very data-driven thanks to our large userbase. Check out our blog to see what engineering at Duolingo can look like: https://blog.duolingo.com/hub/engineering/

Tech stack: (frontends) Swift/Kotlin/TypeScript, (backend) Python/Kotlin/Postgres/Dynamo, (infra) AWS/k8s/Terraform.

We're always hiring for engineers. A few roles below:

Senior Engineering Manager, Chess (NY) https://careers.duolingo.com/jobs/8385137002

Senior Android Engineer (NY) https://careers.duolingo.com/jobs/8217266002

Senior iOS Software Engineer (NY) https://careers.duolingo.com/jobs/8318257002

Engineering Director (London) https://careers.duolingo.com/jobs/8444624002

Senior Gameplay Programmer (London) https://careers.duolingo.com/jobs/8424809002

Base salary: $177-240K for the NY-based roles, unsure about the London-based roles.

Perks: free lunch, 2-week winter break + 20 days of flexible time off.

Decise | Principal Engineer & Technical Strategist | Remote (US) | Fully Remote | Contract (1099)

Decise is a hands-on advisory and delivery firm that helps organizations unlock the full value of their technology and improve business profitability.

We work directly with executives to define what should be built, then we build it. Our work spans software engineering, data platforms, analytics, and customer-facing digital products. We often operate as fractional CIOs and CTOs, guiding both the strategic direction and the technical execution of our clients’ technology initiatives.

Our clients rely on us to turn complex business problems into working systems — not slide decks.

We are intentionally small and senior. Everyone on the team is a builder who can operate independently, solve complex problems, and deliver finished systems that people actually use.

White-glove service. Blue-collar grit.

We’re looking for a principal-level technologist who can move between engineering, architecture, and client strategy. Most of your time will be spent building systems and writing production code. The rest will involve working directly with executives to shape technical direction and ensure the work creates real business value.

Typical technologies we work with include React, Angular, Next.js, Node.js, Go, Snowflake, SQL, dbt, Domo, Streamlit, AWS, Vercel, and modern AI-assisted engineering tools. The exact stack varies by client; the ability to learn quickly and move confidently across technologies matters more than any specific tool.

Strong candidates typically have 10–15 years of experience building production systems and are comfortable operating both as hands-on engineers and as technical advisors to executives.

This is a long-term, full-time independent contractor engagement (1099). Everyone at Decise — including the founders — operates in this structure. Compensation is designed to be competitive with senior engineering roles at leading technology companies.

The fastest way to stand out is to show us something you’ve built: a production system, GitHub repository, application, or data platform you designed.

Apply here: https://www.linkedin.com/jobs/view/4380468950/

PermitFlow (YC W22) | Staff, Fullstack & Frontend Software Engineers | New York, NY | ONSITE | Full-time | https://permitflow.com PermitFlow’s mission is to streamline and simplify construction permitting in the $1.6 trillion United States construction market. Our software reduces time to permit, supporting permitting end-to-end including permit research, application preparation, submission, and monitoring.

We recently raised a $54M Series B led by Accel with participation from Kleiner Perkins, Felicis, Altos Ventures, and YC.

Permitting is a challenging yet interesting problem; thousands of municipalities across the United States have their own processes and requirements - many which are continually updating. Software, AI, and LLMs provide an exciting opportunity for us to reason at scale and distill a nuanced and localized permitting process into a standard and streamlined experience for our customers.

We're looking for customer-obsessed, ambitious, and hard-working teammates who are excited about solving a real-world problem with technology at its helm.

NYC Onsite Roles | apply at: https://jobs.ashbyhq.com/permitflow?departmentId=d33195eb-89...

1. Staff Software Engineer - $200K-275K + equity

2. Fullstack Software Engineer - $125-240K + equity

3. Senior Frontend Engineer - $125K-240K + equity

https://permitflow.com/hiring

Carrot | Senior Software Engineers | Full-time | Remote

Carrot is an all-in-one platform for cannabis dispensaries (ecommerce, loyalty, marketing, apps, and delivery) with a small, high-impact, remote team. We use Scala + Scala.js with functional programming principles, but we value strong programming fundamentals over specific tech stack experience.

What makes this opportunity unique:

- Full remote work with flexible hours (just need availability during US Pacific mornings) - Direct impact on product direction in a growing industry - High autonomy with support through peer reviews and mentorship - Work directly with our CTO in a flat organization

We’re looking for senior engineers excited about working in a functional paradigm. Our interview process is refreshingly streamlined (1-2 interviews).

Full job description: https://www.notion.so/Job-Description-Senior-Full-Stack-Engi... Email seb at getcarrot.io with resumes or questions.

Twindo (Formerly Canvas; The Spatial Computing Company) | Full-time | Remote

At Twindo, we’re working on spatial computing - using computer vision to 3D reconstruct and understand your surroundings so that software can operate over real-world spaces.

Twindo brings together everything that professionals need to understand the spaces they design, build, and manage, without extra site visits or second-guessing. With a quick scan or plan upload, any space becomes structured, accurate, design-ready data your whole team can actually use.

iOS & Backend Engineer (Python) (Europe/LatAm Remote) Chief Product and Technology Officer (Global Remote) Associate Account Executive (Mid Market Sales) (USA Remote) Full Stack Engineer (Backend focus) (Europe/LatAm Remote)

For detailed information check out https://www.twindo.com/careers/

Keywords: 3D, computer vision, photogrammetry, geomatics, SLAM, CAD, iOS, Python

Upvest GmbH | Software Engineers (mid and senior) | SRE Lead | Berlin, Tallinn, London, or REMOTE in Germany, Europe | Full time

At Upvest, we are on a mission to make investing as easy as spending money. Upvest empowers businesses to offer a wide range of investment products and the best experience in the field of capital market investment and retirement planning. Upvest’s Investment API is easy to integrate so that fintechs and financial institutions can save resources and fully focus on their core business.

Roles available:

Senior Software Engineer (f/m/d): https://jobs.ashbyhq.com/upvest/ae836a7b-2b1a-47f6-94a8-1f17... Software Engineer (f/m/d) : https://jobs.ashbyhq.com/upvest/be598062-2fae-46ae-ad14-9828... SRE Lead (f/m/d) - https://jobs.ashbyhq.com/upvest/1b672cdf-b49b-42e7-ace6-b9fb...

If interested, please apply via the links.

Doconomy | Customer Solutions Engineer | Stockholm, Sweden | REMOTE (EU) | Full-Time

https://doconomy.teamtailor.com/jobs/7291339-customer-soluti...

Doconomy, a market leader in impact technology, dedicated to driving global climate action by equipping banks with innovative financial tools that educate and foster positive change.

Our ecosystem of tools combines expertise in behavioral science to design financial services that make it simple and fun to save and invest money, while reducing environmental impact. By integrating these solutions into existing banking apps, we help people achieve their financial goals and contribute to a sustainable future.

Brico (Series A) | San Francisco, CA | ONSITE (Hybrid OK)| H1B Transfer OK | Full-Time | https://www.brico.ai

Brico takes the hassle out of financial licensing for Financial Institutions and FinTechs. We automate new license applications, maintenance, and renewals, creating a 1-stop shop for all licensing needs. Put simply, we are creating from the ground-up dedicated AI-augmented software to manage complex regulatory compliance workflows that used to live in spreadsheets and emails, across all 50+ US jurisdictions.

Our revenue has grown 600% since starting 2.5 years ago, with strong product/market fit and customers such as Marqeta, BitGo, Conduit and Bilt.

We are a small but mighty backend-but-do-it-all engineering team of 6, taking on any challenge that's thrown at us in order to build for and support our growing customer base ranging from ambitious crypto startups to established Fortune 500 financial services companies.

I am hiring senior/staff backend engineers who are also comfortable going up the stack when required to work on our frontend (we are all backend folks). Tech stack: python/django+drf/react

Reach out to me directly (Co-Founder/CTO) at ZW1haWwgZW5naW5lZXJpbmctam9ic0Bicmljby5haSB3aXRoIFtMRVNTVElNRU1PUkVKT1ldIGluIHRoZSB0aXRsZSE=

Microsoft AI | Platform Engineering | Full-time | Greater Seattle Area, WA or Bay Area (Mountain View), CA | ONSITE (4 days/week)

We're building the platform primitives that power https://copilot.com (Microsoft's ChatGPT). If you've shipped systems at scale—whether backend services, distributed infrastructure, ML platforms, or consumer AI products—we want to talk to you.

The work: design and build secure, performant platform services for AI at scale; collaborate with infrastructure, product, design, and research teams; ship high-quality code that reaches hundreds of millions of users; move fast in a design-driven environment.

You: solid fundamentals in systems thinking and software engineering; fluent in Python, C#, C++, Java, JavaScript, or similar; shipped real products or systems people use; can communicate across technical and non-technical teams.

Compensation: Competitive with other frontier AI companies, commensurate with experience. Relocation available.

We're actively hiring and will respond to qualified applicants. Check https://microsoft.ai/careers for current openings, or email maiplatformjobs@microsoft.com if something specific doesn't fit the bill. Apply directly if genuinely interested in building the future of AI.

New grads: If you've had 2+ MAG7+ internships (or adjacent large scale experience) AND a strong transcript from your university. Use [NEW GRAD] in the subject line.

LiveKit | VoiceAI | webRTC | Remote | Full Time | [http://livekit.io/]

LiveKit is building the infrastructure layer for the voice-driven era of computing. Our platform gives developers everything they need to build, test, deploy, scale, and observe agents in production.

Hiring:

>> Senior Software Engineer, Agents: https://jobs.ashbyhq.com/livekit/1757f49e-7e19-4c45-85f7-e46...

>> Distributed Systems Engineer: https://jobs.ashbyhq.com/livekit/938b49cb-4542-46ae-9383-031...

>> Staff Security Engineer: https://jobs.ashbyhq.com/livekit/efc06ff8-37c4-473e-8de8-bbb...

>> Senior Backend Engineer, Billing & Monetization: https://jobs.ashbyhq.com/livekit/bb299eeb-b144-41b2-a654-994...

>> Developer Success Engineer: https://jobs.ashbyhq.com/livekit/fdff28df-2245-43c1-bb09-430...

Co-founders: Russ d'Sa - CEO [https://www.linkedin.com/in/russelldsa/] David Zhao - CTO [https://www.linkedin.com/in/davidzhao/]

Read our most recent blog post on Agents UI Launch: [https://www.notion.so/ViVE-2026-LiveKit-Voice-AI-Target-Comp...]

Prelude | Paris | ONSITE | Full-time

Send verification messages anywhere in the world with the best prices, top deliverability, and zero spam with Prelude - the SMS API powering your growth.

https://prelude.so/

With an ex-Zenly founding team and investment from Seedcamp and Singular, we've already grown to 50 people and signed with X, Sunday, BeReal and more.

Hiring across Engineering (Go, Rust, AWS). We also have a niche role for someone specialising in device fingerprinting where we can be more open minded on remote work or relocation. https://jobs.ashbyhq.com/prelude

Herakles Defense | Munich, Germany | REMOTE| Full-time | Part-time available

Here's the problem: A small drone flies at you at 60mph / 100 km/h You have a camera, one edge processor, and must detect, classify, and track it at 30fps — against sky, trees, buildings. Starting from 100+ meters. If your pipeline drops a single frame at far range, the intercept fails. Sounds impossible? We think together we can solve this.

Now the second problem: Your guidance law needs to predict where that target will be in 0.5 seconds, compute the intercept geometry, and command the flight controller — with noisy IMU data, wind gusts, and a target that doesn't fly in straight lines. No GPS. No RF link. Just onboard compute.

We solved the guidance part in simulation. Our IBVS pipeline tracks and hits moving targets in SITL. The hardware prototype is built and ready. But the real engineering starts now.

We need:

* Computer Vision & Edge AI Engineer — YOLO on Jetson/Hailo/QRB5165. Detect, classify and track small targets at 100m+. Model pruning, TensorRT, sensor fusion. If you've pushed edge hardware to its absolute limits, this is your problem.

* GNC / Flight Systems Engineer — Image base visual servoing, proportional navigation, EKF/UKF state estimation, PX4 integration. Take what works in sim and make it survive real-world sensor noise.

* Simulation & Test Engineer — SITL/HITL, Monte Carlo campaigns, digital twins. 10,000 simulated engagements before anything leaves the ground.

* Technical Advisors — Drone warfare, GNC/aerospace, defense procurement. A few hours/month from the right person changes our trajectory.

We're a pre-seed defense startup in Munich building autonomous interceptor drones to stop FPV kamikaze drones. 2 founders. Salary + equity. No AI screening — we read every application.

https://www.herakles-defense.com/careers

Trunk | https://trunk.io Tech Lead (CI & Test Data Platform) - San Francisco HQ and open to Relo Marketing Lead (Developers) - Remote friendly Developer Advocate - San Francisco HQ and open to Relo Sr Platform Engineer - San Francisco HQ and open to Relo

Trunk is an a16z funded (25M) Series A dev tools startup, redefining software development at scale. At Trunk, our mission is to help teams create high-quality software quickly. AI has made writing code 10x faster, but shipping is still painfully slow. The bottleneck has shifted downstream - to merge conflicts, flaky tests, inconsistent code quality, and dozens of other frictions that drain productivity and morale. Engineering teams that can stay focused on designing, implementing, and delivering software will build magical, high-quality projects - and they'll be happier doing it. We're building a CI Reliability Platform that empowers teams to land code faster and develop happier!

Our products:

  * Merge Queue: Ensure your PRs keep the builds you care about green at any scale.

  *Flaky Tests: Detect and eliminate Flaky Tests.

Frontend: Typescript, React, Next.js, AWS Backend: Typescript, Node, AWS Data pipelines: Dagster, Python, polars CI/CD: GitHub Actions

Unlimited PTO (and we all actually take PTO), competitive salary and equity packages! Please apply here: https://trunk.io/jobs.

Trayd | Engineers + Product / Ops Roles | NYC (ONSITE) https://buildtrayd.com

https://jobs.ashbyhq.com/trayd

Trayd is building the financial operating system for commercial construction. Contractors still run payroll, compliance, and job costing across spreadsheets and legacy software. We replace that stack with a single platform that automates payroll, union compliance, time tracking, and job costing.

Construction payroll alone moves ~$260B annually in the U.S., and most of the industry still runs on outdated tooling. We’re rebuilding that infrastructure from the ground up.

Small, senior team with high ownership. Engineers own systems end to end and work directly with leadership and customers.

Stack: TypeScript, React, Next.js, React Native, Node.js, Postgres

Location: NYC (SoHo office), fully in person.

Open roles Engineering – Senior Software Engineer Product – Product Operations Associate Implementations – Implementations Analyst, Senior Implementations Analyst Customer Success – Customer Success Manager

All roles: https://jobs.ashbyhq.com/trayd